CDC42

CDC42
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4YDH, 1A4R, 1AJE, 1AM4, 1AN0, 1CEE, 1CF4, 1DOA, 1E0A, 1EES, 1GRN, 1GZS, 1KI1, 1KZ7, 1KZG, 1NF3, 2ASE, 2DFK, 2KB0, 2NGR, 2ODB, 2QRZ, 2WM9, 2WMN, 2WMO, 3GCG, 3QBV, 3VHL, 4DID, 4ITR, 4JS0, 4YC7, 5FI1
Dynodwyr
Cyfenwau	CDC42, CDC42Hs, G25K, TKS, cell division cycle 42
Dynodwyr allanol	OMIM: 116952 HomoloGene: 123986 GeneCards: CDC42
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• Rho GDP-dissociation inhibitor binding; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity; • apolipoprotein A-I receptor binding; • GTP-dependent protein binding; • GO:0006184 GTPase activity; • mitogen-activated protein kinase kinase kinase binding; • GO:0001948, GO:0016582 protein binding; • thioesterase binding; • protein kinase binding; • nucleotide binding; • GTP binding; • identical protein binding; • protein serine/threonine kinase activity; • GBD domain binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen; • cell-cell junction; • focal adhesion; • microtubule organizing center; • spindle midzone; • neuron projection; • storage vacuole; • Cytosgerbwd; • cell projection; • myelin sheath; • extracellular exosome; • filopodium; • Cellbilen; • spindle; • apical part of cell; • secretory granule; • neuronal cell body; • cytoplasmic ribonucleoprotein granule; • mitotic spindle; • leading edge membrane; • cyrion cell; • endoplasmic reticulum membrane; • Golgi membrane; • midbody; • centrosome; • cell cortex; • Golgi transport complex; • GO:0009327 protein-containing complex; • dendritic spine;
Prosesau biolegol	• cardiac conduction system development; • positive regulation of protein phosphorylation; • negative regulation of epidermal growth factor receptor signaling pathway; • positive regulation of muscle cell differentiation; • nuclear migration; • keratinization; • positive regulation of JNK cascade; • establishment of Golgi localization; • actin filament bundle assembly; • positive regulation of neuron apoptotic process; • vascular endothelial growth factor receptor signaling pathway; • hair follicle morphogenesis; • heart contraction; • regulation of protein stability; • neuron fate determination; • substantia nigra development; • Fc-gamma receptor signaling pathway involved in phagocytosis; • actin filament organization; • GO:0106160 negative regulation of protein-containing complex assembly; • epithelial-mesenchymal cell signaling; • actin filament branching; • negative regulation of gene expression; • positive regulation of peptidyl-serine phosphorylation; • establishment or maintenance of cell polarity; • positive regulation of cell growth; • regulation of protein metabolic process; • establishment or maintenance of apical/basal cell polarity; • regulation of protein kinase activity; • regulation of attachment of spindle microtubules to kinetochore; • regulation of small GTPase mediated signal transduction; • positive regulation of hair follicle cell proliferation; • positive regulation of MAPK cascade; • regulation of mitotic nuclear division; • hair follicle placode formation; • positive regulation of intracellular protein transport; • cell differentiation; • positive regulation of epithelial cell proliferation involved in lung morphogenesis; • regulation of protein heterodimerization activity; • Golgi organization; • positive regulation of synapse structural plasticity; • multicellular organism growth; • epidermis morphogenesis; • nucleus localization; • epithelial cell-cell adhesion; • sprouting angiogenesis; • nervous system development; • macrophage differentiation; • dendritic cell migration; • positive regulation of cytokinesis; • positive regulation of DNA replication; • Wnt signaling pathway, planar cell polarity pathway; • keratinocyte development; • GO:1903362 regulation of protein catabolic process; • canonical Wnt signaling pathway; • adherens junction organization; • organelle transport along microtubule; • actin cytoskeleton organization; • regulation of filopodium assembly; • endocytosis; • ephrin receptor signaling pathway; • filopodium assembly; • T cell costimulation; • blood coagulation; • positive regulation of phosphatidylinositol 3-kinase activity; • positive regulation of substrate adhesion-dependent cell spreading; • GO:1901313 positive regulation of gene expression; • positive regulation of pseudopodium assembly; • submandibular salivary gland formation; • viral RNA genome replication; • small GTPase mediated signal transduction; • protein ubiquitination; • GO:0048554 positive regulation of catalytic activity; • protein phosphorylation; • phagocytosis, engulfment; • integrin-mediated signaling pathway; • Rho protein signal transduction; • regulation of cell shape; • regulation of lamellipodium assembly; • positive regulation of lamellipodium assembly; • cell projection assembly; • Cdc42 protein signal transduction; • regulation of actin cytoskeleton organization; • cell junction assembly; • interleukin-12-mediated signaling pathway; • neuropilin signaling pathway; • establishment of epithelial cell apical/basal polarity; • positive regulation of filopodium assembly; • regulation of stress fiber assembly; • positive regulation of stress fiber assembly; • dendritic spine morphogenesis; • modification of synaptic structure; • positive regulation of actin cytoskeleton reorganization;
	Sources:Amigo / QuickGO
Orthologau
	998
	n/a
	ENSG00000070831
	n/a
	P60953
	n/a
	NM_044472; NM_001039802; NM_001791
	n/a
	NP_001034891; NP_001782; NP_426359
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDC42 yw CDC42 a elwir hefyd yn Cell division cycle 42 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.12.^[2]

Cyfystyron golygu

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDC42.

TKS
G25K
CDC42Hs

Llyfryddiaeth golygu

"Spatial analysis of Cdc42 activity reveals a role for plasma membrane-associated Cdc42 in centrosome regulation. ". Mol Biol Cell. 2017. PMID 28539409.
"Emerging role of Cdc42-specific guanine nucleotide exchange factors as regulators of membrane trafficking in health and disease. ". Tissue Cell. 2017. PMID 28029388.
"Low Gene Dosage of Cdc42 Is Not Associated with Protein Dysfunction in Patients with Colorectal Cancer. ". DNA Cell Biol. 2016. PMID 27540769.
"Further evidence of a mutation in CDC42 as a cause of a recognizable syndromic form of thrombocytopenia. ". Am J Med Genet A. 2016. PMID 26708094.
"Cdc42 and Cellular Polarity: Emerging Roles at the Golgi.". Trends Cell Biol. 2016. PMID 26704441.

Cyfeiriadau golygu

[1] "Human PubMed Reference:".

[2] CDC42 - Cronfa NCBI

[2]

[1]