CDC6

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDC6 yw CDC6 a elwir hefyd yn Cell division cycle 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.2.

CDC6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CCH, 2CCI, 4I5L, 4I5N
Dynodwyr
Cyfenwau	CDC6, CDC18L, HsCDC18, Hscell division cycle 6, MGORS5
Dynodwyr allanol	OMIM: 602627 HomoloGene: 68172 GeneCards: CDC6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • kinase binding • GO:0001948, GO:0016582 protein binding • ATP binding • DNA replication origin binding Cydrannau o'r gell • spindle pole • spindle midzone • cnewyllyn cell • cytoplasm • nucleolus • nucleoplasm • cytosol Prosesau biolegol • regulation of cyclin-dependent protein serine/threonine kinase activity • cellular response to vasopressin • positive regulation of fibroblast proliferation • negative regulation of DNA replication • regulation of transcription involved in G1/S transition of mitotic cell cycle • Cellraniad • positive regulation of cytokinesis • DNA replication checkpoint signaling • DNA replication • cellular response to angiotensin • DNA replication initiation • traversing start control point of mitotic cell cycle • positive regulation of chromosome segregation • positive regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of mitotic metaphase/anaphase transition • cell cycle • negative regulation of cell population proliferation • GO:0007067 Mitosis • G1/S transition of mitotic cell cycle • mitotic DNA replication checkpoint signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	990	n/a
Ensembl	ENSG00000094804	n/a
UniProt	Q99741	n/a
RefSeq (mRNA)	NM_001254	n/a
RefSeq (protein)	NP_001245	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDC6.

• CDC18L
• HsCDC6
• MGORS5
• HsCDC18

Llyfryddiaeth

• "The DNA replication protein Cdc6 inhibits the microtubule-organizing activity of the centrosome. ". J Biol Chem. 2017. PMID 28827311.
• "High expression of CDC6 is associated with accelerated cell proliferation and poor prognosis of epithelial ovarian cancer. ". Pathol Res Pract. 2016. PMID 26920249.
• "DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation. ". J Cell Sci. 2016. PMID 26872786.
• "Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis. ". Cell Cycle. 2015. PMID 25875233.
• "Cdc6 localizes to S- and G2-phase centrosomes in a cell cycle-dependent manner.". Biochem Biophys Res Commun. 2015. PMID 25498505.