CDK4

CDK4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2W96, 2W99, 2W9F, 2W9Z, 3G33, 5FWL, 5FWM, 5FWK
Dynodwyr
Cyfenwau	CDK4, CMM3, PSK-J3, cyclin-dependent kinase 4, cyclin dependent kinase 4
Dynodwyr allanol	OMIM: 123829 HomoloGene: 55429 GeneCards: CDK4
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • kinase activity; • protein serine/threonine kinase activity; • cyclin-dependent protein serine/threonine kinase regulator activity; • GO:0001948, GO:0016582 protein binding; • ATP binding; • cyclin binding; • cyclin-dependent protein serine/threonine kinase activity; • GO:0032403 protein-containing complex binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • cyclin-dependent protein kinase holoenzyme complex; • nuclear membrane; • bilen; • transcription regulator complex; • bicellular tight junction; • nucleoplasm; • nucleolus; • perinuclear region of cytoplasm; • chromatin; • cnewyllyn cell; • cyclin D2-CDK4 complex; • GO:0009327 protein-containing complex;
Prosesau biolegol	• phosphorylation; • response to testosterone; • positive regulation of fibroblast proliferation; • response to hyperoxia; • positive regulation of translation; • regulation of cell cycle; • Cellraniad; • protein phosphorylation; • lens development in camera-type eye; • regulation of cell population proliferation; • response to lead ion; • Rhythm circadaidd; • animal organ regeneration; • positive regulation of cell population proliferation; • positive regulation of cell size; • positive regulation of apoptotic process; • regulation of gene expression; • cell cycle; • positive regulation of G2/M transition of mitotic cell cycle; • response to toxic substance; • positive regulation of cell cycle; • GO:0072468 signal transduction; • multicellular organism development; • response to organic substance; • cellular response to insulin stimulus; • regulation of multicellular organism growth; • GO:1903104 regulation of insulin receptor signaling pathway; • regulation of lipid biosynthetic process; • regulation of lipid catabolic process; • adipose tissue development; • cellular response to lipopolysaccharide; • cellular response to interleukin-4; • cellular response to phorbol 13-acetate 12-myristate; • cellular response to ionomycin; • transcription initiation from RNA polymerase II promoter; • G1/S transition of mitotic cell cycle; • regulation of cyclin-dependent protein serine/threonine kinase activity; • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologau
	1019
	n/a
	ENSG00000135446
	n/a
	P11802
	n/a
	NM_052984; NM_000075
	n/a
	NP_000066
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CDK4 yw CDK4 a elwir hefyd yn Cyclin-dependent kinase 4 a Cyclin dependent kinase 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q14.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDK4.

CMM3
PSK-J3

Llyfryddiaeth

"CDK4 in lung, and head and neck cancers in old age: evaluation as a biomarker. ". Clin Transl Oncol. 2017. PMID 27815686.
"Direct repression of the oncogene CDK4 by the tumor suppressor miR-486-5p in non-small cell lung cancer. ". Oncotarget. 2016. PMID 27049724.
"Impact of cyclin-dependent kinase CDK4 inhibition on eryptosis. ". Cell Physiol Biochem. 2015. PMID 26418250.
"miR-16 induction after CDK4 knockdown is mediated by c-Myc suppression and inhibits cell growth as well as sensitizes nasopharyngeal carcinoma cells to chemotherapy. ". Tumour Biol. 2016. PMID 26383521.
"CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma.". Clin Cancer Res. 2015. PMID 25810375.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CDK4 - Cronfa NCBI

[2]

[1]