Protein sy'n cael ei godio yn y corff dynol gan y genyn CDKN1A yw CDKN1A a elwir hefyd yn Cyclin dependent kinase inhibitor 1A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.2.[2]
CDKN1A |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/3/34/PDB_1axc_EBI.jpg/250px-PDB_1axc_EBI.jpg) |
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Dynodwyr |
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Cyfenwau | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A |
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Dynodwyr allanol | OMIM: 116899 HomoloGene: 333 GeneCards: CDKN1A |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • metal ion binding • GO:0001948, GO:0016582 protein binding • cyclin-dependent protein serine/threonine kinase inhibitor activity • ubiquitin protein ligase binding • cyclin binding • cyclin-dependent protein kinase activating kinase activity • cyclin-dependent protein serine/threonine kinase activity • protein kinase inhibitor activity • protein kinase binding • GO:0032403 protein-containing complex binding
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Cydrannau o'r gell | • cytoplasm • cytosol • cyclin-dependent protein kinase holoenzyme complex • PCNA-p21 complex • perinuclear region of cytoplasm • cnewyllyn cell • nucleoplasm • nucleolus • nuclear body • GO:0009327 protein-containing complex
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Prosesau biolegol | • cellular response to extracellular stimulus • signal transduction by p53 class mediator • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • cellular response to heat • regulation of cyclin-dependent protein serine/threonine kinase activity • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • positive regulation of cell death • GO:1904578 response to organic cyclic compound • negative regulation of cyclin-dependent protein serine/threonine kinase activity • stress-induced premature senescence • positive regulation of fibroblast proliferation • replicative senescence • response to hyperoxia • response to corticosterone • cellular response to amino acid starvation • positive regulation of programmed cell death • negative regulation of apoptotic process • response to glucocorticoid • response to arsenic-containing substance • regulation of DNA biosynthetic process • response to organic substance • negative regulation of gene expression • cellular response to DNA damage stimulus • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • regulation of cell cycle • intrinsic apoptotic signaling pathway • cellular senescence • positive regulation of reactive oxygen species metabolic process • cellular response to UV-B • G2/M transition of mitotic cell cycle • positive regulation of B cell proliferation • negative regulation of cell growth • response to organonitrogen compound • animal organ regeneration • regulation of mitotic cell cycle • intestinal epithelial cell maturation • cellular response to ionizing radiation • cell cycle • Ras protein signal transduction • negative regulation of phosphorylation • response to toxic substance • response to UV • response to X-ray • negative regulation of cell population proliferation • protein stabilization • positive regulation of cyclin-dependent protein kinase activity • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • positive regulation of protein kinase activity • cellular response to gamma radiation • negative regulation of cyclin-dependent protein kinase activity • transcription initiation from RNA polymerase II promoter • G1/S transition of mitotic cell cycle • cytokine-mediated signaling pathway • negative regulation of vascular associated smooth muscle cell proliferation
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CDKN1A.
- P21
- CIP1
- SDI1
- WAF1
- CAP20
- CDKN1
- MDA-6
- p21CIP1
- "Polyphyllin VII increases sensitivity to gefitinib by modulating the elevation of P21 in acquired gefitinib resistant non-small cell lung cancer. ". J Pharmacol Sci. 2017. PMID 28757172.
- "p21: A Two-Faced Genome Guardian. ". Trends Mol Med. 2017. PMID 28279624.
- "Immunohistochemical study of p21 and Bcl-2 in leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma. ". J Exp Ther Oncol. 2016. PMID 27849339.
- "Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells. ". Elife. 2016. PMID 27740454.
- "Modification of p21 level and cell cycle distribution by 50 Hz magnetic fields in human SH-SY5Y neuroblastoma cells.". Int J Radiat Biol. 2017. PMID 27646005.