CHEK1

Protein sy'n cael ei godio yn y corff dynol gan y genyn CHEK1 yw CHEK1 a elwir hefyd yn Serine/threonine-protein kinase Chk1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q24.2.

CHEK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IA8, 1NVQ, 1NVR, 1NVS, 1ZLT, 1ZYS, 2AYP, 2BR1, 2BRB, 2BRG, 2BRH, 2BRM, 2BRN, 2BRO, 2C3J, 2C3K, 2C3L, 2CGU, 2CGV, 2CGW, 2CGX, 2E9N, 2E9O, 2E9P, 2E9U, 2E9V, 2GDO, 2GHG, 2HOG, 2HXL, 2HXQ, 2HY0, 2QHM, 2QHN, 2R0U, 2WMQ, 2WMR, 2WMS, 2WMT, 2WMU, 2WMV, 2WMW, 2WMX, 2X8D, 2X8E, 2X8I, 2XEY, 2XEZ, 2XF0, 2YDI, 2YDJ, 2YDK, 2YER, 2YEX, 2YM3, 2YM4, 2YM5, 2YM6, 2YM7, 2YM8, 2YWP, 3F9N, 3JVR, 3JVS, 3NLB, 3OT3, 3OT8, 3PA3, 3PA4, 3PA5, 3TKH, 3TKI, 3U9N, 4FSM, 4FSN, 4FSQ, 4FSR, 4FST, 4FSU, 4FSW, 4FSY, 4FSZ, 4FT0, 4FT3, 4FT5, 4FT7, 4FT9, 4FTA, 4FTC, 4FTI, 4FTJ, 4FTK, 4FTL, 4FTM, 4FTN, 4FTO, 4FTQ, 4FTR, 4FTT, 4FTU, 4GH2, 4HYH, 4HYI, 4JIK, 4QYE, 4QYF, 4QYG, 4QYH, 4RVK, 4RVL, 4RVM, 5DLS, 5F4N
Dynodwyr
Cyfenwau	CHEK1, CHK1, checkpoint kinase 1
Dynodwyr allanol	OMIM: 603078 HomoloGene: 975 GeneCards: CHEK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • GO:0001948, GO:0016582 protein binding • ATP binding • kinase activity • protein serine/threonine kinase activity • histone kinase activity (H3-T11 specific) • protein domain specific binding Cydrannau o'r gell • cytosol • centrosome • intracellular membrane-bounded organelle • nucleoplasm • microtubule organizing center • condensed nuclear chromosome • telomere • Cytosgerbwd • cnewyllyn cell • extracellular space • chromatin • cytoplasm • GO:0009327 protein-containing complex Prosesau biolegol • regulation of mitotic centrosome separation • regulation of double-strand break repair via homologous recombination • phosphorylation • replicative senescence • cellular response to DNA damage stimulus • DNA replication • protein phosphorylation • cellular response to mechanical stimulus • negative regulation of mitotic nuclear division • DNA damage induced protein phosphorylation • cell cycle • peptidyl-threonine phosphorylation • regulation of signal transduction by p53 class mediator • GO:0100026 DNA repair • GO:0007243 intracellular signal transduction • regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage • regulation of histone H3-K9 acetylation • DNA damage checkpoint signaling • positive regulation of cell cycle • GO:0097285 apoptotic process • negative regulation of G0 to G1 transition • mitotic G2 DNA damage checkpoint signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1111	n/a
Ensembl	ENSG00000149554	n/a
UniProt	O14757	n/a
RefSeq (mRNA)	NM_001114121 NM_001114122 NM_001244846 NM_001274 NM_001330427 NM_001330428	n/a
RefSeq (protein)	NP_001107593 NP_001107594 NP_001231775 NP_001265 NP_001317356 NP_001317357	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CHEK1.

• CHK1

Llyfryddiaeth

• "Genetic variants in CHEK1 gene are associated with the prognosis of thoracic esophageal squamous cell carcinoma patients treated with radical resection. ". J Huazhong Univ Sci Technolog Med Sci. 2016. PMID 27924519.
• "CHK1 as a therapeutic target to bypass chemoresistance in AML. ". Sci Signal. 2016. PMID 27625304.
• "A balanced pyrimidine pool is required for optimal Chk1 activation to prevent ultrafine anaphase bridge formation. ". J Cell Sci. 2016. PMID 27383768.
• "Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-ROS pathway sensitizes esophageal cancer cells to 5-fluorouracil-induced cell death via the CHEK1-mediated DNA damage checkpoint. ". Autophagy. 2016. PMID 27310928.
• "Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage.". J Biol Chem. 2016. PMID 27129240.