CHP1

Protein sy'n cael ei godio yn y corff dynol gan y genyn CHP1 yw CHP1 a elwir hefyd yn Calcineurin B homologous protein 1 a Calcineurin like EF-hand protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q15.1.

CHP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2E30
Dynodwyr
Cyfenwau	CHP1, CHP, SLC9A1BP, Sid470p, p22, p24, calcineurin like EF-hand protein 1, SPAX9
Dynodwyr allanol	OMIM: 606988 HomoloGene: 5235 GeneCards: CHP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • transporter activity • microtubule binding • protein kinase inhibitor activity • metal ion binding • calcium-dependent protein binding • potassium channel regulator activity • kinase binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • focal adhesion • microtubule cytoskeleton • Golgi membrane • Cellbilen • transport vesicle • Reticwlwm endoplasmig • extracellular exosome • Cytosgerbwd • endomembrane system • cnewyllyn cell • endoplasmic reticulum-Golgi intermediate compartment Prosesau biolegol • GO:0033128 negative regulation of protein phosphorylation • GO:0090284 positive regulation of protein glycosylation • negative regulation of calcineurin-NFAT signaling cascade • hyaluronan catabolic process • negative regulation of protein autophosphorylation • negative regulation of protein kinase activity • positive regulation of sodium:proton antiporter activity • negative regulation of phosphatase activity • small GTPase mediated signal transduction • protein stabilization • cellular response to acidic pH • membrane fusion • regulation of intracellular pH • positive regulation of protein transport • negative regulation of protein ubiquitination • potassium ion transport • protein complex oligomerization • microtubule bundle formation • cytoplasmic microtubule organization • protein export from nucleus • membrane docking • regulation of neuron death • protein transport • membrane organization • negative regulation of NF-kappaB transcription factor activity • calcium-ion regulated exocytosis • positive regulation of protein targeting to membrane • negative regulation of protein import into nucleus • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11261	n/a
Ensembl	ENSG00000187446	n/a
UniProt	Q99653	n/a
RefSeq (mRNA)	NM_007236	n/a
RefSeq (protein)	NP_009167	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CHP1.

• CHP
• p22
• p24
• Sid470p
• SLC9A1BP

Llyfryddiaeth

• "Structural characterization of calcineurin B homologous protein 1. ". J Biol Chem. 2005. PMID 15987692.
• "A novel Ca2+-binding protein, p22, is required for constitutive membrane traffic. ". J Biol Chem. 1996. PMID 8626580.
• "Nuclear-localized calcineurin homologous protein CHP1 interacts with upstream binding factor and inhibits ribosomal RNA synthesis. ". J Biol Chem. 2010. PMID 20720019.
• "Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1. ". J Biol Chem. 2007. PMID 17050540.
• "Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1.". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID 16511206.