CORO1A

Protein sy'n cael ei godio yn y corff dynol gan y genyn CORO1A yw CORO1A a elwir hefyd yn Coronin a Coronin 1a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p11.2.

CORO1A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AKF, 2AQ5, 2B4E
Dynodwyr
Cyfenwau	CORO1A, CLABP, CLIPINA, HCORO1, IMD8, TACO, p57, coronin 1A
Dynodwyr allanol	OMIM: 605000 HomoloGene: 6545 GeneCards: CORO1A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protein C-terminus binding • identical protein binding • phosphatidylinositol 3-kinase binding • protein homodimerization activity • actin monomer binding • myosin heavy chain binding • cytoskeletal protein binding • actin filament binding • actin binding Cydrannau o'r gell • phagocytic cup • extracellular exosome • cytoplasm • actin cytoskeleton • cell cortex • cnewyllyn cell • cell leading edge • axon • lamellipodium • cortical actin cytoskeleton • early endosome • cell-cell junction • bilen • Microffilament • phagocytic vesicle membrane • Cellbilen • GO:0016023 cytoplasmic vesicle • immunological synapse • Cytosgerbwd • phagocytic vesicle • cytosol Prosesau biolegol • negative regulation of vesicle fusion • calcium ion transport • homeostasis of number of cells within a tissue • negative regulation of actin nucleation • ffagocytosis • response to cytokine • nerve growth factor signaling pathway • T cell homeostasis • positive regulation of cell migration • regulation of actin cytoskeleton organization • positive chemotaxis • actin filament organization • positive regulation of T cell proliferation • cellular response to interleukin-4 • natural killer cell degranulation • regulation of release of sequestered calcium ion into cytosol • regulation of actin polymerization or depolymerization • cell-substrate adhesion • regulation of actin filament polymerization • GO:1904089 negative regulation of neuron apoptotic process • positive regulation of T cell activation • regulation of cell shape • innate immune response • early endosome to recycling endosome transport • cell migration • actin cytoskeleton organization • uropod organization • immunological synapse formation • leukocyte chemotaxis • phagolysosome assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11151	n/a
Ensembl	ENSG00000102879	n/a
UniProt	P31146	n/a
RefSeq (mRNA)	NM_001193333 NM_007074	n/a
RefSeq (protein)	NP_001180262 NP_009005	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CORO1A.

• p57
• IMD8
• TACO
• CLABP
• HCORO1
• CLIPINA

Llyfryddiaeth

• "Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy. ". J Clin Immunol. 2014. PMID 25073507.
• "Identification of coronin-1a as a novel antibody target for clinically isolated syndrome and multiple sclerosis. ". J Neurochem. 2013. PMID 23745754.
• "Emergent Role of Coronin-1a in Neuronal Signaling. ". Vitam Horm. 2017. PMID 28215292.
• "Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association. ". J Allergy Clin Immunol. 2016. PMID 26476480.
• "Coronin 1 trimerization is essential to protect pathogenic mycobacteria within macrophages from lysosomal delivery.". FEBS Lett. 2014. PMID 25217836.