CRHR1

Protein sy'n cael ei godio yn y corff dynol gan y genyn CRHR1 yw CRHR1 a elwir hefyd yn Corticotropin releasing hormone receptor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.31.

CRHR1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4K5Y, 3EHU, 2L27, 3EHS, 3EHT, 4Z9G
Dynodwyr
Cyfenwau	CRHR1, CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRH-R1h, CRHR, CRHR1L, CRHR1f, corticotropin releasing hormone receptor 1
Dynodwyr allanol	OMIM: 122561 HomoloGene: 20920 GeneCards: CRHR1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • G protein-coupled receptor activity • signal transducer activity • GO:0001948, GO:0016582 protein binding • corticotrophin-releasing factor receptor activity • transmembrane signaling receptor activity • peptide hormone binding • corticotropin-releasing hormone receptor activity • corticotropin-releasing hormone binding • G-protein alpha-subunit binding • peptide binding • GO:0032403 protein-containing complex binding Cydrannau o'r gell • integral component of membrane • endosome • bilen • intrinsic component of plasma membrane • Cellbilen • integral component of plasma membrane • multivesicular body • trans-Golgi network • dendrite • fesigl • soma • apical part of cell Prosesau biolegol • corticotropin secretion • female pregnancy • activation of adenylate cyclase activity • regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • genedigaeth • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • cellular response to corticotropin-releasing hormone stimulus • regulation of corticosterone secretion • negative regulation of voltage-gated calcium channel activity • GO:0072468 signal transduction • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • hormone-mediated signaling pathway • response to hypoxia • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • neuropeptide signaling pathway • Cof • feeding behavior • visual learning • hypothalamus development • adrenal gland development • epithelial cell differentiation • negative regulation of epinephrine secretion • locomotory exploration behavior • response to immobilization stress • fear response • positive regulation of mast cell degranulation • positive regulation of cAMP-mediated signaling • behavioral response to cocaine • behavioral response to ethanol • regulation of synaptic plasticity • behavioral response to pain • response to electrical stimulus • general adaptation syndrome, behavioral process • long-term potentiation • negative regulation of neuron death • negative regulation of feeding behavior Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1394	n/a
Ensembl	n/a	n/a
UniProt	P34998	n/a
RefSeq (mRNA)	NM_001145146 NM_001145147 NM_001145148 NM_004382 NM_001303018 NM_001303020	n/a
RefSeq (protein)	NP_001138618 NP_001138619 NP_001138620 NP_001289947 NP_001289949 NP_004373	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CRHR1.

• CRF1
• CRHR
• CRF-R
• CRFR1
• CRF-R1
• CRFR-1
• CRH-R1
• CRHR1L
• CRF-R-1
• CRH-R-1

Llyfryddiaeth

• "Region-specific roles of the corticotropin-releasing factor-urocortin system in stress. ". Nat Rev Neurosci. 2016. PMID 27586075.
• "Effects of corticotropin-releasing hormone receptor 1 SNPs on major depressive disorder are influenced by sex and smoking status. ". J Affect Disord. 2016. PMID 27544317.
• "Corticotropin-releasing hormone receptor 1 (CRH-R1) polymorphisms are associated with irritable bowel syndrome and acoustic startle response. ". Psychoneuroendocrinology. 2016. PMID 27497153.
• "Allelic variation in CRHR1 predisposes to panic disorder: evidence for biased fear processing. ". Mol Psychiatry. 2016. PMID 26324098.
• "Family Economic Hardship, Corticotropin-Releasing Hormone Receptor Polymorphisms, and Depressive Symptoms in Rural African-American Youths.". J Adolesc Health. 2015. PMID 26206446.