CSF1R

Protein sy'n cael ei godio yn y corff dynol gan y genyn CSF1R yw CSF1R a elwir hefyd yn Colony stimulating factor 1 receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q32.

CSF1R
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM
Dynodwyr
Cyfenwau	CSF1R, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R, colony stimulating factor 1 receptor, BANDDOS, HDLS1
Dynodwyr allanol	OMIM: 164770 HomoloGene: 3817 GeneCards: CSF1R
EC number	2.7.10.1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • protein tyrosine kinase activity • protein kinase activity • transferase activity • transmembrane receptor protein tyrosine kinase activity • kinase activity • protein homodimerization activity • ATP binding • protein phosphatase binding • macrophage colony-stimulating factor receptor activity • GO:0019974 cytokine binding • GO:0001948, GO:0016582 protein binding • receptor tyrosine kinase • transmembrane signaling receptor activity Cydrannau o'r gell • integral component of membrane • integral component of plasma membrane • bilen • cell surface • CSF1-CSF1R complex • nucleoplasm • Cellbilen • intracellular membrane-bounded organelle • cytoplasm • receptor complex Prosesau biolegol • negative regulation of cell population proliferation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of protein serine/threonine kinase activity • mammary gland duct morphogenesis • positive regulation of cell motility • macrophage colony-stimulating factor signaling pathway • phosphatidylinositol-mediated signaling • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • GO:0072468 signal transduction • axon guidance • multicellular organism development • monocyte differentiation • macrophage differentiation • ruffle organization • positive regulation of cell migration • cellular response to cytokine stimulus • protein autophosphorylation • peptidyl-tyrosine phosphorylation • olfactory bulb development • regulation of bone resorption • phosphatidylinositol metabolic process • protein phosphorylation • positive regulation of protein tyrosine kinase activity • cell-cell junction maintenance • osteoclast differentiation • innate immune response • regulation of actin cytoskeleton reorganization • immune system process • inflammatory response • positive regulation of protein phosphorylation • forebrain neuron differentiation • phosphorylation • cellular response to macrophage colony-stimulating factor stimulus • positive regulation of cell population proliferation • regulation of cell shape • cell population proliferation • positive regulation of tyrosine phosphorylation of STAT protein • cytokine-mediated signaling pathway • hemopoiesis • negative regulation of signal transduction • cell differentiation • hematopoietic progenitor cell differentiation • positive regulation of MAPK cascade • response to ischemia • microglial cell proliferation • positive regulation by host of viral process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1436	n/a
Ensembl	ENSG00000182578	n/a
UniProt	P07333	n/a
RefSeq (mRNA)	NM_001288705 NM_005211 NM_001349736 NM_001375320 NM_001375321	n/a
RefSeq (protein)	NP_001275634 NP_005202 NP_001336665 NP_001362249 NP_001362250	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CSF1R.

• FMS
• CSFR
• FIM2
• HDLS
• C-FMS
• CD115
• CSF-1R
• M-CSF-R

Llyfryddiaeth

• "Clinical and genetic characterization of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia associated with CSF1R mutation. ". Eur J Neurol. 2017. PMID 27680516.
• "Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS): update on molecular genetics. ". Neurol Sci. 2016. PMID 27338940.
• "CSF1R mosaicism in a family with hereditary diffuse leukoencephalopathy with spheroids. ". Brain. 2016. PMID 27190017.
• "Overexpression of CSF-1R in nasopharyngeal carcinoma. ". Rom J Morphol Embryol. 2015. PMID 26743272.
• "High Expression of Colony-Stimulating Factor 1 Receptor Associates with Unfavorable Cancer-Specific Survival of Patients with Clear Cell Renal Cell Carcinoma.". Ann Surg Oncol. 2016. PMID 26467457.