CTLA4

Protein sy'n cael ei godio yn y corff dynol gan y genyn CTLA4 yw CTLA4 a elwir hefyd yn Cytotoxic T-lymphocyte associated protein 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q33.2.

CTLA4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3OSK, 1AH1, 1H6E, 1I85, 1I8L, 2X44, 3BX7
Dynodwyr
Cyfenwau	CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4
Dynodwyr allanol	OMIM: 123890 HomoloGene: 3820 GeneCards: CTLA4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • perinuclear region of cytoplasm • integral component of membrane • clathrin-coated endocytic vesicle • Cellbilen • Golgi apparatus • bilen • external side of plasma membrane • protein complex involved in cell adhesion • integral component of plasma membrane Prosesau biolegol • B cell receptor signaling pathway • T cell costimulation • negative regulation of B cell proliferation • adaptive immune response • negative regulation of regulatory T cell differentiation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • cellular response to DNA damage stimulus • immune system process • positive regulation of apoptotic process • negative regulation of immune response • negative regulation of T cell proliferation • regulation of regulatory T cell differentiation • regulation of T cell proliferation • T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1493	n/a
Ensembl	ENSG00000163599	n/a
UniProt	P16410	n/a
RefSeq (mRNA)	NM_001037631 NM_005214	n/a
RefSeq (protein)	NP_001032720 NP_005205	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CTLA4.

• CD
• GSE
• GRD4
• ALPS5
• CD152
• CTLA-4
• IDDM12
• CELIAC3

Llyfryddiaeth

• "CD25-expressing Th17 cells mediate CD8+ T cell suppression in CTLA-4 dependent mechanisms in pancreatic ductal adenocarcinoma. ". Exp Cell Res. 2017. PMID 28942020.
• "CTLA-4 expression in the non-small cell lung cancer patient tumor microenvironment: diverging prognostic impact in primary tumors and lymph node metastases. ". Cancer Immunol Immunother. 2017. PMID 28707078.
• "CTLA-4 +49 G/A Polymorphism Confers Autoimmune Disease Risk: An Updated Meta-Analysis. ". Genet Test Mol Biomarkers. 2017. PMID 28384040.
• "CTLA-4 gene polymorphisms associate with efficacy of postoperative radioiodine-131 for differentiated thyroid carcinoma. ". Future Oncol. 2017. PMID 28326838.
• "[Association between CTLA-4 gene polymorphism and Henoch-Schönlein purpura in children].". Zhongguo Dang Dai Er Ke Za Zhi. 2017. PMID 28302200.