CTSC

Protein sy'n cael ei godio yn y corff dynol gan y genyn CTSC yw CTSC a elwir hefyd yn Cathepsin C (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q14.2.

CTSC
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4OEM, 1K3B, 2DJF, 2DJG, 3PDF, 4CDC, 4CDD, 4CDE, 4CDF, 4OEL
Dynodwyr
Cyfenwau	CTSC, CPPI, DPP-I, DPP1, DPPI, HMS, JP, JPD, PALS, PDON1, PLS, cathepsin C
Dynodwyr allanol	OMIM: 602365 HomoloGene: 1373 GeneCards: CTSC
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase activator activity involved in apoptotic process • phosphatase binding • cysteine-type peptidase activity • chaperone binding • protein self-association • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • identical protein binding • chloride ion binding • cysteine-type endopeptidase activity • serine-type endopeptidase activity • hydrolase activity Cydrannau o'r gell • Golgi apparatus • endoplasmic reticulum lumen • bilen • Reticwlwm endoplasmig • COPII-coated ER to Golgi transport vesicle • lysosome • extracellular exosome • endoplasmic reticulum-Golgi intermediate compartment membrane • Golgi membrane • extracellular region • extracellular space • nucleoplasm • centrosome • azurophil granule lumen • intracellular membrane-bounded organelle • collagen-containing extracellular matrix • cytoplasm Prosesau biolegol • GO:0010260 heneiddio • positive regulation of proteolysis involved in cellular protein catabolic process • positive regulation of apoptotic signaling pathway • response to organic substance • proteolysis • endoplasmic reticulum to Golgi vesicle-mediated transport • COPII vesicle coating • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • proteolysis involved in cellular protein catabolic process • T cell mediated cytotoxicity • GO:0097285 apoptotic process • neutrophil degranulation • negative regulation of myelination • positive regulation of microglial cell activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1075	n/a
Ensembl	ENSG00000109861	n/a
UniProt	P53634	n/a
RefSeq (mRNA)	NM_148170 NM_001114173 NM_001814	n/a
RefSeq (protein)	NP_001107645 NP_001805 NP_680475	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CTSC.

• JP
• HMS
• JPD
• PLS
• CPPI
• DPP1
• DPPI
• PALS
• DPP-I
• PDON1

Llyfryddiaeth

• "Development of the first internally-quenched fluorescent substrates of human cathepsin C: The application in the enzyme detection in biological samples. ". Arch Biochem Biophys. 2016. PMID 27746119.
• "Papillon-Lefèvre syndrome: report of six patients and identification of a novel mutation. ". Int J Dermatol. 2016. PMID 27062382.
• "[Screening of CTSC gene mutations in a Chinese pedigree affected with Papillon-Lefevre syndrome]. ". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016. PMID 27060303.
• "A novel large deletion combined with a nonsense mutation in a Chinese child with Papillon-Lefèvre syndrome. ". J Periodontal Res. 2016. PMID 26385525.
• "One mutation, two phenotypes: a single nonsense mutation of the CTSC gene causes two clinically distinct phenotypes.". Clin Exp Dermatol. 2016. PMID 26205983.