CUL3

Protein sy'n cael ei godio yn y corff dynol gan y genyn CUL3 yw CUL3 a elwir hefyd yn Cullin-3 a Cullin 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q36.2.

CUL3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2MYL, 2MYM, 4AP2, 4APF, 4EOZ, 4HXI
Dynodwyr
Cyfenwau	CUL3, CUL-3, PHA2E, cullin 3, NEDAUS
Dynodwyr allanol	OMIM: 603136 HomoloGene: 2661 GeneCards: CUL3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • POZ domain binding • protein homodimerization activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • GO:0050372 ubiquitin-protein transferase activity • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • ubiquitin protein ligase binding • cyclin binding • Notch binding Cydrannau o'r gell • cytoplasm • cullin-RING ubiquitin ligase complex • cytosol • Golgi apparatus • bilen • Cul3-RING ubiquitin ligase complex • nucleoplasm • polar microtubule • extracellular exosome • cnewyllyn cell • Golgi membrane • cilium • SCF ubiquitin ligase complex • motile cilium • sperm flagellum • cell projection Prosesau biolegol • embryonic cleavage • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • G1 phase • negative regulation of Rho protein signal transduction • protein polyubiquitination • in utero embryonic development • GO:1901227 negative regulation of transcription by RNA polymerase II • Wnt signaling pathway • protein monoubiquitination • stress fiber assembly • MAPK cascade • positive regulation of cytokinesis • intrinsic apoptotic signaling pathway • endoplasmic reticulum to Golgi vesicle-mediated transport • positive regulation of mitotic metaphase/anaphase transition • COPII vesicle coating • fibroblast apoptotic process • cell projection organization • gastrulation • stem cell division • protein ubiquitination • GO:0000767 cell morphogenesis • positive regulation of cell population proliferation • GO:0007067 Mitosis • integrin-mediated signaling pathway • mitotic metaphase plate congression • cell migration • negative regulation of canonical Wnt signaling pathway • vesicle-mediated transport • liver morphogenesis • proteasome-mediated ubiquitin-dependent protein catabolic process • trophectodermal cellular morphogenesis • ubiquitin-dependent protein catabolic process • anaphase-promoting complex-dependent catabolic process • nuclear protein quality control by the ubiquitin-proteasome system • post-translational protein modification • GO:0015915 transport • G1/S transition of mitotic cell cycle • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • positive regulation of protein ubiquitination • protein destabilization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8452	n/a
Ensembl	ENSG00000036257	n/a
UniProt	Q13618	n/a
RefSeq (mRNA)	NM_001257197 NM_001257198 NM_003590	n/a
RefSeq (protein)	NP_001244126 NP_001244127 NP_003581	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CUL3.

• CUL-3
• PHA2E

Llyfryddiaeth

• "Cullin 3 as a novel target in diverse pathologies. ". Redox Biol. 2013. PMID 24024173.
• "A young child with pseudohypoaldosteronism type II by a mutation of Cullin 3. ". BMC Nephrol. 2013. PMID 23902721.
• "Prospect of divergent roles for the CUL3 system in vascular endothelial cell function and angiogenesis. ". J Biochem. 2017. PMID 28981750.
• "New insights into the function of Cullin 3 in trophoblast invasion and migration. ". Reproduction. 2015. PMID 26021998.
• "Cullin3-BTB interface: a novel target for stapled peptides.". PLoS One. 2015. PMID 25848797.