DAB2

Protein sy'n cael ei godio yn y corff dynol gan y genyn DAB2 yw DAB2 a elwir hefyd yn DAB2, clathrin adaptor protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5p13.1.

DAB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2LSW
Dynodwyr
Cyfenwau	DAB2, DOC-2, DOC2, clathrin adaptor protein, DAB adaptor protein 2
Dynodwyr allanol	OMIM: 601236 HomoloGene: 1026 GeneCards: DAB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • clathrin adaptor activity • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • cargo receptor activity • SMAD binding Cydrannau o'r gell • cytoplasm • intracellular membrane-bounded organelle • bilen • focal adhesion • Cellbilen • lysosomal membrane • nucleolus • clathrin-coated vesicle membrane • clathrin-coated pit • extracellular exosome • GO:0016023 cytoplasmic vesicle • clathrin-coated vesicle • fibrillar center • cytosol Prosesau biolegol • positive regulation of transforming growth factor beta receptor signaling pathway • cell differentiation • positive regulation of protein phosphorylation • endocytosis • positive regulation of cell migration • positive regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of androgen receptor signaling pathway • negative regulation of apoptotic process • Wnt signaling pathway • negative regulation of protein binding • positive regulation of epithelial to mesenchymal transition • leading edge cell differentiation • multicellular organism development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of endocytosis • negative regulation of protein localization to plasma membrane • positive regulation of clathrin-dependent endocytosis • protein transport • positive regulation of early endosome to late endosome transport • integrin-mediated signaling pathway • positive regulation of Wnt signaling pathway, planar cell polarity pathway • cell population proliferation • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of canonical Wnt signaling pathway • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • positive regulation of SMAD protein signal transduction • GO:0097285 apoptotic process • receptor-mediated endocytosis • membrane organization • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1601	n/a
Ensembl	ENSG00000153071	n/a
UniProt	P98082	n/a
RefSeq (mRNA)	NM_001343 NM_001244871	n/a
RefSeq (protein)	NP_001231800 NP_001334	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DAB2.

• DOC2
• DOC-2

Llyfryddiaeth

• "Disabled homolog 2 is required for migration and invasion of prostate cancer cells. ". Front Med. 2015. PMID 26143155.
• "Aberrant Hypermethylation at Sites -86 to 226 of DAB2 Gene in Non-Small Cell Lung Cancer. ". Am J Med Sci. 2015. PMID 25719979.
• "Distinct effects of Disabled-2 on transferrin uptake in different cell types and culture conditions. ". Cell Biol Int. 2014. PMID 24889971.
• "Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-β. ". Mol Biol Cell. 2014. PMID 24648493.
• "The expression of disabled-2 is common reduced in meningiomas.". Neurol India. 2014. PMID 24608456.