DDR2

Protein sy'n cael ei godio yn y corff dynol gan y genyn DDR2 yw DDR2 a elwir hefyd yn Discoidin domain receptor tyrosine kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q23.3.

DDR2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2WUH, 2Z4F
Dynodwyr
Cyfenwau	DDR2, MIG20a, NTRKR3, TKT, TYRO10, discoidin domain receptor tyrosine kinase 2, WRCN
Dynodwyr allanol	OMIM: 191311 HomoloGene: 68505 GeneCards: DDR2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • kinase activity • GO:0001948, GO:0016582 protein binding • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase collagen receptor activity • protein tyrosine kinase activity • ATP binding • collagen binding Cydrannau o'r gell • integral component of membrane • bilen • focal adhesion • integral component of plasma membrane • extracellular exosome • apical plasma membrane • Cellbilen • actin cytoskeleton • receptor complex Prosesau biolegol • collagen-activated tyrosine kinase receptor signaling pathway • ossification • phosphorylation • collagen fibril organization • transmembrane receptor protein tyrosine kinase signaling pathway • regulation of bone mineralization • positive regulation of fibroblast proliferation • biomineral tissue development • positive regulation of DNA-binding transcription factor activity • extracellular matrix organization • regulation of extracellular matrix disassembly • positive regulation of extracellular matrix disassembly • protein phosphorylation • cell adhesion • positive regulation of osteoblast differentiation • chondrocyte proliferation • positive regulation of cell population proliferation • peptidyl-tyrosine phosphorylation • endochondral bone growth • positive regulation of fibroblast migration • GO:0072468 signal transduction • positive regulation of protein kinase activity • protein autophosphorylation • regulation of cell-matrix adhesion • cell-matrix adhesion • cell differentiation • regulation of extracellular matrix organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4921	n/a
Ensembl	ENSG00000162733	n/a
UniProt	Q16832	n/a
RefSeq (mRNA)	NM_001014796 NM_006182 NM_001354982 NM_001354983	n/a
RefSeq (protein)	NP_001014796 NP_006173 NP_001341911 NP_001341912	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DDR2.

• TKT
• MIG20a
• NTRKR3
• TYRO10

Llyfryddiaeth

• "DDR2 Expression Is Associated with a High Frequency of Peritoneal Dissemination and Poor Prognosis in Colorectal Cancer. ". Anticancer Res. 2017. PMID 28476831.
• "Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth. ". Cell Rep. 2017. PMID 28147276.
• "Targeting of Discoidin Domain Receptor 2 (DDR2) Prevents Myofibroblast Activation and Neovessel Formation During Pulmonary Fibrosis. ". Mol Ther. 2016. PMID 27350126.
• "Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression.". Oncotarget. 2016. PMID 27121132.
• "DDR2 Induces Gastric Cancer Cell Activities via Activating mTORC2 Signaling and Is Associated with Clinicopathological Characteristics of Gastric Cancer.". Dig Dis Sci. 2016. PMID 27010547.