DEFB1

Protein sy'n cael ei godio yn y corff dynol gan y genyn DEFB1 yw DEFB1 a elwir hefyd yn Defensin beta 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8p23.1.

DEFB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1E4S, 1IJU, 1IJV, 1KJ5, 2NLB, 2NLC, 2NLD, 2NLE, 2NLF, 2NLG, 2NLH, 2NLP, 2NLQ, 2NLS, 2PLZ
Dynodwyr
Cyfenwau	DEFB1, BD1, DEFB-1, DEFB101, HBD1, defensin beta 1
Dynodwyr allanol	OMIM: 602056 HomoloGene: 88476 GeneCards: DEFB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • CCR6 chemokine receptor binding • GO:0001948, GO:0016582 protein binding • identical protein binding Cydrannau o'r gell • Golgi lumen • extracellular region • extracellular exosome • sperm midpiece • extracellular space • extrinsic component of membrane • microvesicle • bilen Prosesau biolegol • chemotaxis • G protein-coupled receptor signaling pathway • defense response • innate immune response in mucosa • acute inflammatory response • response to bacterium • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • response to testosterone • positive regulation of flagellated sperm motility involved in capacitation • defense response to bacterium • calcium-mediated signaling using intracellular calcium source • cAMP-mediated signaling • GO:0051636 defense response to Gram-negative bacterium • antimicrobial humoral response • innate immune response • antimicrobial humoral immune response mediated by antimicrobial peptide • GO:0051637 defense response to Gram-positive bacterium Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1672	n/a
Ensembl	ENSG00000164825 ENSG00000284881	n/a
UniProt	P60022	n/a
RefSeq (mRNA)	NM_005218	n/a
RefSeq (protein)	NP_005209	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DEFB1.

• BD1
• HBD1
• DEFB-1
• DEFB101

Llyfryddiaeth

• "A role of human beta defensin-1 in predicting prostatic adenocarcinoma in cases of false-negative biopsy. ". APMIS. 2017. PMID 28885732.
• "Early type I Interferon response induces upregulation of human β-defensin 1 during acute HIV-1 infection. ". PLoS One. 2017. PMID 28253319.
• "Caries and Innate Immunity: DEFB1 Gene Polymorphisms and Caries Susceptibility in Genetic Isolates from North-Eastern Italy. ". Caries Res. 2016. PMID 27846636.
• "DNA Methylation-Mediated Downregulation of DEFB1 in Prostate Cancer Cells. ". PLoS One. 2016. PMID 27835705.
• "DEFB1 polymorphisms and salivary hBD-1 concentration in Oral Lichen Planus patients and healthy subjects.". Arch Oral Biol. 2017. PMID 27770642.