DLC1

Protein sy'n cael ei godio yn y corff dynol gan y genyn DLC1 yw DLC1 a elwir hefyd yn Rho GTPase-activating protein 7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8p22.

DLC1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DKY, 2GYT, 2KAP, 2LOZ, 3KUQ, 5FZT
Dynodwyr
Cyfenwau	DLC1, ARHGAP7, HP, STARD12, p122-RhoGAP, DLC1 Rho GTPase activating protein
Dynodwyr allanol	OMIM: 604258 HomoloGene: 4442 GeneCards: DLC1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • SH2 domain binding • GO:0001948, GO:0016582 protein binding • lipid binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity Cydrannau o'r gell • cytosol • bilen • ruffle membrane • cell junction • cortical actin cytoskeleton • caveola • cnewyllyn cell • cytoplasm • focal adhesion Prosesau biolegol • positive regulation of execution phase of apoptosis • regulation of actin cytoskeleton organization • positive regulation of protein dephosphorylation • negative regulation of Rho protein signal transduction • heart morphogenesis • focal adhesion assembly • neural tube closure • regulation of cell shape • hindbrain morphogenesis • forebrain development • negative regulation of stress fiber assembly • regulation of Rho protein signal transduction • activation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of small GTPase mediated signal transduction • negative regulation of focal adhesion assembly • actin cytoskeleton organization • GO:0072468 signal transduction • negative regulation of cell population proliferation • GO:0097285 apoptotic process • negative regulation of cell migration • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10395	n/a
Ensembl	ENSG00000164741 ENSG00000288673	n/a
UniProt	Q96QB1	n/a
RefSeq (mRNA)	NM_001164271 NM_001316668 NM_006094 NM_024767 NM_182643 NM_001348081 NM_001348082 NM_001348083 NM_001348084	n/a
RefSeq (protein)	NP_001157743 NP_001303597 NP_006085 NP_079043 NP_872584 NP_001335010 NP_001335011 NP_001335012 NP_001335013	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DLC1.

• HP
• ARHGAP7
• STARD12
• p122-RhoGAP

Llyfryddiaeth

• "rs621554 single nucleotide polymorphism of DLC1 is associated with breast cancer susceptibility and prognosis. ". Mol Med Rep. 2016. PMID 26986853.
• "DLC-1 is an independent prognostic marker and potential therapeutic target in hepatocellular cancer. ". Diagn Pathol. 2016. PMID 26846339.
• "Curcumin inhibits growth of human breast cancer cells through demethylation of DLC1 promoter. ". Mol Cell Biochem. 2017. PMID 27830358.
• "Aberrant DNA methylation of alternative promoter of DLC1 isoform 1 in meningiomas. ". J Neurooncol. 2016. PMID 27614886.
• "The Role of Tumor Suppressor DLC-1: Far From Clear.". Anticancer Agents Med Chem. 2017. PMID 27604574.