DLG5

DLG5
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1UIT
Dynodwyr
Cyfenwau	DLG5, LP-DLG, P-PDLG, discs large homolog 5, discs large MAGUK scaffold protein 5
Dynodwyr allanol	OMIM: 604090 HomoloGene: 3486 GeneCards: DLG5
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• beta-catenin binding; • cytoskeletal protein binding; • GO:0001948, GO:0016582 protein binding; • signaling receptor complex adaptor activity;
Cydrannau o'r gell	• bilen; • Cellbilen; • cell junction; • GO:0097483, GO:0097481 postsynaptic density; • ciliary basal body; • cytoplasm; • Cytosgerbwd; • cell projection; • synapse; • postsynaptic membrane;
Prosesau biolegol	• regulation of apoptotic process; • polarized epithelial cell differentiation; • GO:0007243 intracellular signal transduction; • apical protein localization; • establishment or maintenance of epithelial cell apical/basal polarity; • protein localization to adherens junction; • metanephric collecting duct development; • epithelial tube branching involved in lung morphogenesis; • zonula adherens assembly; • midbrain development; • GO:0072468 signal transduction; • negative regulation of cell population proliferation; • epithelial to mesenchymal transition; • maintenance of cell polarity; • negative regulation of cell migration; • negative regulation of hippo signaling; • positive regulation of hippo signaling; • negative regulation of T cell proliferation; • positive regulation of smoothened signaling pathway; • positive regulation of synapse assembly; • positive regulation of dendritic spine development; • cell-cell adhesion; • GO:0034622 protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologau
	9231
	n/a
	ENSG00000151208; ENSG00000274429
	n/a
	Q8TDM6
	n/a
	NM_004747
	n/a
	NP_004738
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DLG5 yw DLG5 a elwir hefyd yn Discs large MAGUK scaffold protein 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q22.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DLG5.

PDLG
LP-DLG
P-DLG5

Llyfryddiaeth

"DLG5 in cell polarity maintenance and cancer development. ". Int J Biol Sci. 2014. PMID 24910533.
"DLG5 P1371Q is associated with inflammatory bowel disease and complementary to R30Q in disease susceptibility. ". Swiss Med Wkly. 2011. PMID 22065243.
"The association of DLG5 polymorphisms with inflammatory bowel disease: a meta-analysis of 25 studies. ". Eur Rev Med Pharmacol Sci. 2016. PMID 27338058.
"Discs Large Homolog 5 (DLG5) Gene Polymorphism and Crohn's Disease: A Meta-Analysis of the Published Studies. ". Acta Med Iran. 2016. PMID 27309475.
"Methylation-mediated silencing of Dlg5 facilitates bladder cancer metastasis.". Exp Cell Res. 2015. PMID 25478998.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] DLG5 - Cronfa NCBI

[2]

[1]