DLX2

DLX2
Dynodwyr
Cyfenwau	DLX2, TES-1, TES1, AW121999, Dlx-2, distal-less homeobox 2
Dynodwyr allanol	OMIM: 126255 HomoloGene: 3244 GeneCards: DLX2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • chromatin binding; • GO:0001948, GO:0016582 protein binding; • single-stranded RNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cydrannau o'r gell	• cnewyllyn cell;
Prosesau biolegol	• cerebral cortex GABAergic interneuron differentiation; • proximal/distal pattern formation; • cell differentiation; • GO:0009373 regulation of transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • branching morphogenesis of a nerve; • embryonic skeletal system development; • multicellular organism development; • odontogenesis of dentin-containing tooth; • cerebral cortex GABAergic interneuron fate commitment; • cartilage development; • brain development; • negative regulation of oligodendrocyte differentiation; • forebrain neuron differentiation; • embryonic cranial skeleton morphogenesis; • olfactory bulb development; • hippocampus development; • subpallium development; • negative regulation of Notch signaling pathway; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of cell differentiation; • negative regulation of photoreceptor cell differentiation; • positive regulation of amacrine cell differentiation; • transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologau
	1746
	n/a
	ENSG00000115844
	n/a
	Q07687
	n/a
	NM_004405
	n/a
	NP_004396; NP_004396.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DLX2 yw DLX2 a elwir hefyd yn Distal-less homeobox 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q31.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DLX2.

TES1
TES-1

Llyfryddiaeth

"Overexpression of DLX2 is associated with poor prognosis and sorafenib resistance in hepatocellular carcinoma. ". Exp Mol Pathol. 2016. PMID 27302463.
"A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. ". Genes Dev. 2016. PMID 26833729.
"Smad2/3-Regulated Expression of DLX2 Is Associated with Radiation-Induced Epithelial-Mesenchymal Transition and Radioresistance of A549 and MDA-MB-231 Human Cancer Cell Lines. ". PLoS One. 2016. PMID 26799321.
"Dlx-2 is implicated in TGF-β- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation. ". Int J Oncol. 2015. PMID 25651912.
"Increased expression of DLX2 correlates with advanced stage of gastric adenocarcinoma.". World J Gastroenterol. 2013. PMID 23674878.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] DLX2 - Cronfa NCBI

[2]

[1]