DNASE1

Protein sy'n cael ei godio yn y corff dynol gan y genyn DNASE1 yw DNASE1 a elwir hefyd yn Deoxyribonuclease 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p13.3.

DNASE1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4AWN
Dynodwyr
Cyfenwau	DNASE1, DNL1, DRNI, deoxyribonuclease I, deoxyribonuclease 1
Dynodwyr allanol	OMIM: 125505 HomoloGene: 3826 GeneCards: DNASE1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nuclease activity • endonuclease activity • deoxyribonuclease I activity • actin binding • GO:0001948, GO:0016582 protein binding • hydrolase activity • deoxyribonuclease activity • DNA binding Cydrannau o'r gell • extracellular region • extracellular exosome • nuclear envelope • cnewyllyn cell Prosesau biolegol • DNA catabolic process • nucleic acid phosphodiester bond hydrolysis • GO:0097285 apoptotic process • DNA catabolic process, endonucleolytic • neutrophil activation involved in immune response • regulation of acute inflammatory response • regulation of neutrophil mediated cytotoxicity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1773	n/a
Ensembl	ENSG00000213918	n/a
UniProt	P24855	n/a
RefSeq (mRNA)	NM_005223 NM_001351825 NM_001387135 NM_001387139 NM_001387140 NM_001387141	n/a
RefSeq (protein)	NP_005214 NP_001338754	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DNASE1.

• DNL1
• DRNI

Llyfryddiaeth

• "Decreased serum DNase1-activity in patients with autoimmune liver diseases. ". Autoimmunity. 2017. PMID 28263100.
• "Association between severe disease course and nephritis with Q222R polymorphism in DNAse I gene among lupus patients: An Argentine multicenter study. ". Acta Reumatol Port. 2016. PMID 27606473.
• "DNase I aggravates islet β-cell apoptosis in type 2 diabetes. ". Mol Med Rep. 2016. PMID 27082840.
• "Deoxyribonuclease I gene polymorphism and susceptibility to systemic lupus erythematosus. ". Clin Rheumatol. 2016. PMID 26547219.
• "Global analysis of genetic variations in a 56-bp variable number of tandem repeat polymorphisms within the human deoxyribonuclease I gene.". Leg Med (Tokyo). 2015. PMID 25771153.