DNMT3B

Protein sy'n cael ei godio yn y corff dynol gan y genyn DNMT3B yw DNMT3B a elwir hefyd yn DNA methyltransferase 3 beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q11.21.

DNMT3B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3QKJ, 3FLG, 5CIU
Dynodwyr
Cyfenwau	DNMT3B, ICF, ICF1, M.HsaIIIB, DNA (cytosine-5-)-methyltransferase 3 beta, DNA methyltransferase 3 beta, FSHD4
Dynodwyr allanol	OMIM: 602900 HomoloGene: 56000 GeneCards: DNMT3B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0102674, GO:0102675 methyltransferase activity • transferase activity • DNA binding • GO:0001106 transcription corepressor activity • DNA-methyltransferase activity • chromatin binding • metal ion binding • GO:0001948, GO:0016582 protein binding • DNA (cytosine-5-)-methyltransferase activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • histone deacetylase binding Cydrannau o'r gell • cytoplasm • intracellular membrane-bounded organelle • nucleoplasm • cnewyllyn cell Prosesau biolegol • response to ionizing radiation • C-5 methylation of cytosine • response to estradiol • response to hypoxia • cellular response to hyperoxia • GO:1901227 negative regulation of transcription by RNA polymerase II • response to activity • cellular response to dexamethasone stimulus • response to vitamin A • DNA methylation • methylation • GO:1901313 positive regulation of gene expression • negative regulation of gene expression, epigenetic • positive regulation of histone H3-K4 methylation • positive regulation of neuron differentiation • negative regulation of histone H3-K9 methylation • regulation of gene expression • response to caffeine • response to toxic substance • adwaith i gocên Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1789	n/a
Ensembl	ENSG00000088305	n/a
UniProt	Q9UBC3	n/a
RefSeq (mRNA)	NM_001207055 NM_001207056 NM_006892 NM_175848 NM_175849 NM_175850	n/a
RefSeq (protein)	NP_001193984 NP_001193985 NP_008823 NP_787044 NP_787045 NP_787046	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DNMT3B.

• ICF
• ICF1
• M.HsaIIIB

Llyfryddiaeth

• "ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing. ". Nucleic Acids Res. 2017. PMID 28334849.
• "Kaempferol Modulates DNA Methylation and Downregulates DNMT3B in Bladder Cancer. ". Cell Physiol Biochem. 2017. PMID 28278502.
• "Association between DNA methyltransferase gene polymorphism and Parkinson's disease. ". Neurosci Lett. 2017. PMID 28041964.
• "Associations of DNMT3B -149C>T and -2437T>A polymorphisms and lung cancer risk in Chinese population. ". World J Surg Oncol. 2016. PMID 27876061.
• "A Novel Mutation in a Critical Region for the Methyl Donor Binding in DNMT3B Causes Immunodeficiency, Centromeric Instability, and Facial Anomalies Syndrome (ICF).". J Clin Immunol. 2016. PMID 27734333.