DNMT3L

Protein sy'n cael ei godio yn y corff dynol gan y genyn DNMT3L yw DNMT3L a elwir hefyd yn DNA methyltransferase 3 like a DNA (cytosine-5)-methyltransferase 3-like (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 21, band 21q22.3.

DNMT3L
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2PV0, 2PVC, 2QRV, 4U7P, 4U7T
Dynodwyr
Cyfenwau	DNMT3L, DNA methyltransferase 3 like
Dynodwyr allanol	OMIM: 606588 HomoloGene: 8362 GeneCards: DNMT3L
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • enzyme binding • GO:0010576 enzyme regulator activity • GO:0010577 enzyme activator activity • GO:0001948, GO:0016582 protein binding • metal ion binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytosol • cnewyllyn cell • ESC/E(Z) complex Prosesau biolegol • regulation of gene expression by genetic imprinting • DNA methylation • GO:0048552 regulation of catalytic activity • GO:0045996 negative regulation of transcription, DNA-templated • GO:0048554 positive regulation of catalytic activity • male meiosis I • spermatogenesis • cell differentiation • DNA methylation on cytosine • DNA methylation involved in gamete generation • stem cell differentiation • negative regulation of DNA methylation • positive regulation of DNA methylation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	29947	n/a
Ensembl	ENSG00000142182	n/a
UniProt	Q9UJW3	n/a
RefSeq (mRNA)	NM_013369 NM_175867	n/a
RefSeq (protein)	NP_037501 NP_787063	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Llyfryddiaeth

• "Hypomethylation of the DNMT3L promoter in ocular surface squamous neoplasia. ". Arch Pathol Lab Med. 2010. PMID 20670142.
• "DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma. ". Clin Cancer Res. 2010. PMID 20460473.
• "Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility. ". Mol Med Rep. 2016. PMID 26647998.
• "Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis. ". Am J Pathol. 2012. PMID 22401780.
• "Association between single-nucleotide polymorphisms of DNMT3L and infertility with azoospermia in Chinese men.". Reprod Biomed Online. 2012. PMID 22116073.