DRD2

DRD2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	6CM4
Dynodwyr
Cyfenwau	DRD2, D2DR, D2R, dopamine receptor D2
Dynodwyr allanol	OMIM: 126450 HomoloGene: 22561 GeneCards: DRD2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein homodimerization activity; • potassium channel regulator activity; • dopamine neurotransmitter receptor activity, coupled via Gi/Go; • identical protein binding; • dopamine neurotransmitter receptor activity; • G protein-coupled receptor activity; • GO:0001948, GO:0016582 protein binding; • signal transducer activity; • adrenergic receptor activity; • dopamine binding; • signaling receptor binding; • ionotropic glutamate receptor binding; • protein heterodimerization activity;
Cydrannau o'r gell	• GO:0016023 cytoplasmic vesicle; • sperm flagellum; • endocytic vesicle; • acrosomal vesicle; • dendritic spine; • synaptic vesicle membrane; • perikaryon; • Cellbilen; • dendrite; • ciliary membrane; • axon terminus; • integral component of membrane; • GO:0097483, GO:0097481 postsynaptic density; • bilen; • lateral plasma membrane; • axon; • intracellular anatomical structure; • non-motile cilium; • integral component of plasma membrane; • dopaminergic synapse; • glutamatergic synapse; • GABA-ergic synapse; • integral component of postsynaptic membrane; • integral component of presynaptic membrane;
Prosesau biolegol	• negative regulation of cell population proliferation; • temperature homeostasis; • adenylate cyclase-inhibiting dopamine receptor signaling pathway; • adenohypophysis development; • circadian regulation of gene expression; • response to toxic substance; • regulation of dopamine secretion; • adwaith i gocên; • response to amphetamine; • sensory perception of smell; • locomotory behavior; • positive regulation of urine volume; • response to ethanol; • axonogenesis; • response to inactivity; • phospholipase C-activating dopamine receptor signaling pathway; • modulation of chemical synaptic transmission; • grooming behavior; • negative regulation of protein kinase B signaling; • associative learning; • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; • regulation of dopamine uptake involved in synaptic transmission; • regulation of synaptic transmission, GABAergic; • positive regulation of dopamine uptake involved in synaptic transmission; • GO:0072468 signal transduction; • Wnt signaling pathway; • adult walking behavior; • branching morphogenesis of a nerve; • negative regulation of cytosolic calcium ion concentration; • negative regulation of innate immune response; • regulation of phosphoprotein phosphatase activity; • acid secretion; • feeding behavior; • positive regulation of G protein-coupled receptor signaling pathway; • response to axon injury; • striatum development; • synaptic transmission, dopaminergic; • nervous system process involved in regulation of systemic arterial blood pressure; • peristalsis; • regulation of long-term neuronal synaptic plasticity; • activation of protein kinase activity; • positive regulation of growth hormone secretion; • regulation of sodium ion transport; • forebrain development; • response to light stimulus; • orbitofrontal cortex development; • prepulse inhibition; • response to morphine; • response to iron ion; • positive regulation of ERK1 and ERK2 cascade; • long-term memory; • positive regulation of renal sodium excretion; • negative regulation of insulin secretion; • neuron-neuron synaptic transmission; • GO:0007243 intracellular signal transduction; • auditory behavior; • behavioral response to ethanol; • regulation of heart rate; • adenylate cyclase-activating adrenergic receptor signaling pathway; • positive regulation of cytokinesis; • regulation of potassium ion transport; • pigmentation; • cellular calcium ion homeostasis; • dopamine metabolic process; • response to nicotine; • regulation of MAPK cascade; • response to histamine; • negative regulation of synaptic transmission, glutamatergic; • response to hypoxia; • negative regulation of circadian sleep/wake cycle, sleep; • negative regulation of protein secretion; • synapse assembly; • regulation of locomotion involved in locomotory behavior; • dopamine receptor signaling pathway; • negative regulation of dopamine receptor signaling pathway; • startle response; • positive regulation of receptor internalization; • GO:0034613 protein localization; • arachidonic acid secretion; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • G protein-coupled receptor internalization; • positive regulation of multicellular organism growth; • positive regulation of long-term synaptic potentiation; • negative regulation of dopamine secretion; • adult behavior; • cerebral cortex GABAergic interneuron migration; • regulation of synapse structural plasticity; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • visual learning; • negative regulation of cell migration; • behavioral response to cocaine; • positive regulation of neuroblast proliferation; • negative regulation of blood pressure; • release of sequestered calcium ion into cytosol; • negative regulation of voltage-gated calcium channel activity; • G protein-coupled receptor signaling pathway; • negative regulation of adenylate cyclase activity; • excitatory postsynaptic potential; • GO:0033128 negative regulation of protein phosphorylation; • autophagy; • positive regulation of neurogenesis; • negative regulation of cell death; • drinking behavior; • adrenergic receptor signaling pathway; • regulation of neurotransmitter uptake; • postsynaptic modulation of chemical synaptic transmission; • regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologau
	1813
	n/a
	ENSG00000149295
	n/a
	P14416
	n/a
	NM_016574; NM_000795
	n/a
	NP_000786; NP_057658; NP_000786.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DRD2 yw DRD2 a elwir hefyd yn Dopamine receptor D2, isoform CRA_c (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q23.2.^[2]

Cyfystyron golygu

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DRD2.

D2R
D2DR

Llyfryddiaeth golygu

"The impact of common dopamine D2 receptor gene polymorphisms on D2/3 receptor availability: C957T as a key determinant in putamen and ventral striatum. ". Transl Psychiatry. 2017. PMID 28398340.
"Association of the dopamine D2 receptor rs1800497 polymorphism and eating behavior in Chilean children. ". Nutrition. 2017. PMID 28241982.
"DRD2 co-expression network and a related polygenic index predict imaging, behavioral and clinical phenotypes linked to schizophrenia. ". Transl Psychiatry. 2017. PMID 28094815.
"Activation of D2 Dopamine Receptors in CD133+ve Cancer Stem Cells in Non-small Cell Lung Carcinoma Inhibits Proliferation, Clonogenic Ability, and Invasiveness of These Cells. ". J Biol Chem. 2017. PMID 27920206.
"Dopamine-2 receptor extracellular N-terminus regulates receptor surface availability and is the target of human pathogenic antibodies from children with movement and psychiatric disorders.". Acta Neuropathol Commun. 2016. PMID 27908295.

Cyfeiriadau golygu

[1] "Human PubMed Reference:".

[2] DRD2 - Cronfa NCBI

[2]

[1]