DYRK1A

Protein sy'n cael ei godio yn y corff dynol gan y genyn DYRK1A yw DYRK1A a elwir hefyd yn Dual specificity tyrosine phosphorylation regulated kinase 1A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 21, band 21q22.13.

DYRK1A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2VX3, 2WO6, 3ANQ, 3ANR, 4AZE, 4MQ1, 4MQ2, 4NCT, 4YLJ, 4YLK, 4YLL, 4YU2, 5AIK, 5A4Q, 5A4E, 5A3X, 5A4T, 5A54, 5A4L
Dynodwyr
Cyfenwau	DYRK1A, DYRK, DYRK1, HP86, MNB, MNBH, MRD7, dual specificity tyrosine phosphorylation regulated kinase 1A
Dynodwyr allanol	OMIM: 600855 HomoloGene: 55576 GeneCards: DYRK1A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • non-membrane spanning protein tyrosine kinase activity • kinase activity • protein self-association • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • protein serine/threonine/tyrosine kinase activity • protein tyrosine kinase activity • tau protein binding • ATP binding • identical protein binding • tau-protein kinase activity Cydrannau o'r gell • nuclear speck • nucleoplasm • cnewyllyn cell • cytoplasm • Cytosgerbwd • axon • dendrite • ribonucleoprotein complex Prosesau biolegol • positive regulation of protein deacetylation • phosphorylation • regulation of alternative mRNA splicing, via spliceosome • nervous system development • protein phosphorylation • negative regulation of mRNA splicing, via spliceosome • negative regulation of DNA damage response, signal transduction by p53 class mediator • GO:0035404 peptidyl-serine phosphorylation • Rhythm circadaidd • protein autophosphorylation • peptidyl-tyrosine phosphorylation • peptidyl-threonine phosphorylation • GO:0022415 viral process • negative regulation of microtubule polymerization • positive regulation of RNA splicing • amyloid-beta formation • peptidyl-serine autophosphorylation • peptidyl-tyrosine autophosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1859	n/a
Ensembl	ENSG00000157540	n/a
UniProt	Q13627	n/a
RefSeq (mRNA)	NM_001396 NM_101395 NM_130436 NM_130437 NM_130438 NM_001347721 NM_001347722 NM_001347723	n/a
RefSeq (protein)	NP_001334650 NP_001334651 NP_001334652 NP_001387 NP_567824 NP_569120 NP_569122	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DYRK1A.

• MNB
• DYRK
• HP86
• MNBH
• MRD7
• DYRK1

Llyfryddiaeth

• "Structural analysis of pathogenic mutations in the DYRK1A gene in patients with developmental disorders. ". Hum Mol Genet. 2017. PMID 28053047.
• "Association of DYRK1A polymorphisms with sporadic Parkinson's disease in Chinese Han population. ". Neurosci Lett. 2016. PMID 27546826.
• "Case report of novel DYRK1A mutations in 2 individuals with syndromic intellectual disability and a review of the literature. ". BMC Med Genet. 2016. PMID 26922654.
• DYRK1A-Related Intellectual Disability Syndrome. 1993. PMID 26677511.
• "DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner.". PLoS One. 2015. PMID 26641855.