DYRK2

Protein sy'n cael ei godio yn y corff dynol gan y genyn DYRK2 yw DYRK2 a elwir hefyd yn Dual-specificity tyrosine-phosphorylation-regulated kinase 2 a Dual specificity tyrosine phosphorylation regulated kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q15.

DYRK2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3K2L, 3KVW, 4AZF
Dynodwyr
Cyfenwau	DYRK2, dual specificity tyrosine phosphorylation regulated kinase 2
Dynodwyr allanol	OMIM: 603496 HomoloGene: 48437 GeneCards: DYRK2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • manganese ion binding • kinase activity • GO:0001948, GO:0016582 protein binding • protein serine/threonine/tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • magnesium ion binding • protein serine/threonine kinase activity Cydrannau o'r gell • cytoplasm • ubiquitin ligase complex • cnewyllyn cell • nucleoplasm • cytosol • ribonucleoprotein complex Prosesau biolegol • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • positive regulation of glycogen biosynthetic process • phosphorylation • cellular response to DNA damage stimulus • protein phosphorylation • smoothened signaling pathway • GO:0097285 apoptotic process • regulation of signal transduction by p53 class mediator • peptidyl-tyrosine phosphorylation • negative regulation of calcineurin-NFAT signaling cascade Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8445	n/a
Ensembl	ENSG00000127334	n/a
UniProt	Q92630	n/a
RefSeq (mRNA)	NM_006482 NM_003583	n/a
RefSeq (protein)	NP_003574 NP_006473	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Llyfryddiaeth

• "Silencing of DYRK2 increases cell proliferation but reverses CAM-DR in Non-Hodgkin's Lymphoma. ". Int J Biol Macromol. 2015. PMID 26341817.
• "DYRK2 regulates epithelial-mesenchymal-transition and chemosensitivity through Snail degradation in ovarian serous adenocarcinoma. ". Tumour Biol. 2015. PMID 25712377.
• "Dual-specificity tyrosine-regulated kinase 2 is a suppressor and potential prognostic marker for liver metastasis of colorectal cancer. ". Cancer Sci. 2017. PMID 28502078.
• "Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer. ". PLoS One. 2016. PMID 27532268.
• "Downregulated DYRK2 expression is associated with poor prognosis and Oxaliplatin resistance in hepatocellular carcinoma.". Pathol Res Pract. 2016. PMID 26804244.