E2F1

Protein sy'n cael ei godio yn y corff dynol gan y genyn E2F1 yw E2F1 a elwir hefyd yn E2F transcription factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20q11.22.

E2F1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1H24, 1O9K, 2AZE
Dynodwyr
Cyfenwau	E2F1, E2F-1, RBAP1, RBBP3, RBP3, E2F transcription factor 1
Dynodwyr allanol	OMIM: 189971 HomoloGene: 3828 GeneCards: E2F1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • GO:0001948, GO:0016582 protein binding • protein dimerization activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • protein kinase binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • transcription regulator complex • Rb-E2F complex • cnewyllyn cell • mitocondria • nucleoplasm • centrosome • GO:0009327 protein-containing complex • RNA polymerase II transcription regulator complex Prosesau biolegol • cellular response to nerve growth factor stimulus • negative regulation of fat cell differentiation • GO:0009373 regulation of transcription, DNA-templated • lens fiber cell apoptotic process • negative regulation of transcription involved in G1/S transition of mitotic cell cycle • positive regulation of fibroblast proliferation • negative regulation of DNA binding • negative regulation of fat cell proliferation • DNA damage checkpoint signaling • cellular response to xenobiotic stimulus • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • regulation of cell cycle • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • regulation of G1/S transition of mitotic cell cycle • mRNA stabilization • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • GO:1901313 positive regulation of gene expression • cellular response to fatty acid • anoikis • spermatogenesis • intrinsic apoptotic signaling pathway in response to DNA damage • intrinsic apoptotic signaling pathway by p53 class mediator • cell cycle • forebrain development • GO:0045996 negative regulation of transcription, DNA-templated • cellular response to hypoxia • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0097285 apoptotic process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • regulation of transcription involved in G1/S transition of mitotic cell cycle • positive regulation of apoptotic process • negative regulation of G0 to G1 transition • positive regulation of glial cell proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1869	n/a
Ensembl	ENSG00000101412	n/a
UniProt	Q01094	n/a
RefSeq (mRNA)	NM_005225	n/a
RefSeq (protein)	NP_005216	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn E2F1.

• RBP3
• E2F-1
• RBAP1
• RBBP3

Llyfryddiaeth

• "E2F1 somatic mutation within miRNA target site impairs gene regulation in colorectal cancer. ". PLoS One. 2017. PMID 28704519.
• "Resveratrol enhances the radiosensitivity of nasopharyngeal carcinoma cells by downregulating E2F1. ". Oncol Rep. 2017. PMID 28184930.
• "A functional variant at the miRNA binding site in E2F1 gene is associated with risk and tumor HPV16 status of oropharynx squamous cell carcinoma. ". Mol Carcinog. 2017. PMID 27677255.
• "Characterizing Genetic Transitions of Copy Number Alterations and Allelic Imbalances in Oral Tongue Carcinoma Metastasis. ". Genes Chromosomes Cancer. 2016. PMID 27461516.
• "Sustained E2F-Dependent Transcription Is a Key Mechanism to Prevent Replication-Stress-Induced DNA Damage.". Cell Rep. 2016. PMID 27160911.