EFNA5

Protein sy'n cael ei godio yn y corff dynol gan y genyn EFNA5 yw EFNA5 a elwir hefyd yn Ephrin A5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q21.3.

EFNA5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2X11, 3MX0, 4BK5, 4BKA, 4L0P, 4M4R
Dynodwyr
Cyfenwau	EFNA5, AF1, EFL5, EPLG7, GLC1M, LERK7, RAGS, ephrin A5
Dynodwyr allanol	OMIM: 601535 HomoloGene: 1482 GeneCards: EFNA5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • neurotrophin TRKC receptor binding • transmembrane receptor protein tyrosine kinase activator activity • neurotrophin TRKA receptor binding • ephrin receptor binding • chemorepellent activity • neurotrophin TRKB receptor binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • bilen • Cellbilen • anchored component of external side of plasma membrane • caveola • anchored component of membrane • basement membrane • adherens junction • cyrion cell • GABA-ergic synapse Prosesau biolegol • positive regulation of synapse assembly • GO:0097285 apoptotic process • cell differentiation • regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of protein phosphorylation • negative chemotaxis • regulation of actin cytoskeleton organization • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • ephrin receptor signaling pathway • regulation of microtubule cytoskeleton organization • positive regulation of collateral sprouting • nervous system development • multicellular organism development • regulation of cell-cell adhesion • positive regulation of peptidyl-tyrosine phosphorylation • regulation of focal adhesion assembly • regulation of cell morphogenesis • collateral sprouting • negative regulation of substrate adhesion-dependent cell spreading • retinal ganglion cell axon guidance • cellular response to follicle-stimulating hormone stimulus • cellular response to forskolin • activation of transmembrane receptor protein tyrosine kinase activity • axon guidance • synaptic membrane adhesion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1946	n/a
Ensembl	ENSG00000184349	n/a
UniProt	P52803	n/a
RefSeq (mRNA)	NM_001962	n/a
RefSeq (protein)	NP_001953	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EFNA5.

• AF1
• EFL5
• RAGS
• EPLG7
• GLC1M
• LERK7

Llyfryddiaeth

• "Mutational screening of EFNA5 in Chinese age-related cataract patients. ". Ophthalmic Res. 2014. PMID 25300504.
• "Peritumoral small ephrinA5 isoform level predicts the postoperative survival in hepatocellular carcinoma. ". PLoS One. 2012. PMID 22860012.
• "EphrinA5 suppresses colon cancer development by negatively regulating epidermal growth factor receptor stability. ". FEBS J. 2012. PMID 22074469.
• "Down-regulation of ephrin-A5, a gene product of normal cartilage, in chondrosarcoma. ". Hum Pathol. 2009. PMID 19695673.
• "A subset of signal transduction pathways is required for hippocampal growth cone collapse induced by ephrin-A5.". Dev Neurobiol. 2008. PMID 18563700.