ERBB2

Protein sy'n cael ei godio yn y corff dynol gan y genyn ERBB2 yw ERBB2 a elwir hefyd yn Erb-b2 receptor tyrosine kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q12.

ERBB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3N85, 3PP0, 3RCD, 3MZW, 3WLW, 3WSQ, 4GFU, 4HRL, 4HRM, 4HRN, 2N2A
Dynodwyr
Cyfenwau	ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2
Dynodwyr allanol	OMIM: 164870 HomoloGene: 3273 GeneCards: ERBB2
EC number	2.7.10.1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ErbB-3 class receptor binding • transferase activity • nucleotide binding • protein kinase activity • protein dimerization activity • growth factor binding • RNA polymerase I core binding • kinase activity • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • identical protein binding • protein heterodimerization activity • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • protein phosphatase binding • ATP binding • transmembrane signaling receptor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • receptor tyrosine kinase Cydrannau o'r gell • integral component of membrane • bilen • myelin sheath • receptor complex • Cellbilen • basolateral plasma membrane • apical plasma membrane • perinuclear region of cytoplasm • endosome membrane • GO:0016023 cytoplasmic vesicle • cnewyllyn cell • cytoplasm • cytosol • integral component of plasma membrane • basal plasma membrane Prosesau biolegol • positive regulation of protein phosphorylation • peripheral nervous system development • GO:0009373 regulation of transcription, DNA-templated • negative regulation of immature T cell proliferation in thymus • positive regulation of MAP kinase activity • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of epithelial cell proliferation • cellular response to growth factor stimulus • wound healing • oligodendrocyte differentiation • regulation of angiogenesis • positive regulation of translation • transcription, DNA-templated • nervous system development • MAPK cascade • protein phosphorylation • heart development • cell surface receptor signaling pathway • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • positive regulation of cell growth • regulation of microtubule-based process • neuromuscular junction development • regulation of ERK1 and ERK2 cascade • myelination • protein autophosphorylation • phosphatidylinositol 3-kinase signaling • positive regulation of transcription by RNA polymerase I • cell population proliferation • positive regulation of transcription by RNA polymerase III • motor neuron axon guidance • enzyme linked receptor protein signaling pathway • GO:0072468 signal transduction • positive regulation of cell adhesion • positive regulation of protein targeting to membrane • ERBB2 signaling pathway • phosphatidylinositol phosphate biosynthetic process • GO:1901313 positive regulation of gene expression • peptidyl-tyrosine phosphorylation • regulation of cell motility • cellular response to epidermal growth factor stimulus • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of ERBB signaling pathway • positive regulation of protein kinase B signaling • negative regulation of signal transduction • cell differentiation • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • GO:0007243 intracellular signal transduction • positive regulation of cell population proliferation • neuron differentiation • positive regulation of MAPK cascade Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2064	n/a
Ensembl	ENSG00000141736	n/a
UniProt	P04626	n/a
RefSeq (mRNA)	NM_001005862 NM_001289936 NM_001289937 NM_001289938 NM_004448	n/a
RefSeq (protein)	NP_001005862 NP_001276865 NP_001276866 NP_001276867 NP_004439 NP_001369711 NP_001369712 NP_001369713 NP_001369714 NP_001369715 NP_001369716 NP_001369717 NP_001369718 NP_001369719 NP_001369720 NP_001369721 NP_001369722 NP_001369723 NP_001369724 NP_001369725 NP_001369726 NP_001369727 NP_001369728 NP_001369729 NP_001369730 NP_001369731 NP_001369732 NP_001369733 NP_001369734 NP_001369735	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ERBB2.

• NEU
• NGL
• HER2
• TKR1
• CD340
• HER-2
• MLN*19
• HER-2/neu

Llyfryddiaeth

• "Evaluation of Expression of Human Epidermal Growth Factor Receptor 2 (HER2) in Gastric and Gastroesophageal Junction Adenocarcinoma Using IHC and Dual-ISH. ". Anticancer Res. 2018. PMID 29277796.
• "Outcome Evaluation of HER2 Breast Cancer Patients with Limited Brain Metastasis. ". Anticancer Res. 2017. PMID 29187495.
• "Prognostic value of tumour-infiltrating lymphocytes in small HER2-positive breast cancer. ". Eur J Cancer. 2017. PMID 29154173.
• "Quantifying HER-2 expression on circulating tumor cells by ACCEPT. ". PLoS One. 2017. PMID 29084234.
• "Vinorelbine Plus Gemcitabine or Cisplatin as First-line Treatment of HER2-negative Advanced Breast Cancer.". Anticancer Res. 2017. PMID 28982882.