FAF1

Protein sy'n cael ei godio yn y corff dynol gan y genyn FAF1 yw FAF1 a elwir hefyd yn Fas associated factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p32.3.

FAF1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1H8C, 2DZM, 2EC4, 3E21, 3QC8, 3QCA, 3QQ8, 3QWZ, 3QX1, 3R3M
Dynodwyr
Cyfenwau	FAF1, HFAF1s, UBXD12, UBXN3A, hCGI-03, Fas associated factor 1
Dynodwyr allanol	OMIM: 604460 HomoloGene: 5120 GeneCards: FAF1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • heat shock protein binding • protein domain specific binding • NF-kappaB binding • ubiquitin binding • GO:0001948, GO:0016582 protein binding • protein kinase regulator activity • protein kinase binding • ubiquitin protein ligase binding Cydrannau o'r gell • cytoplasm • cytosol • CD95 death-inducing signaling complex • nuclear envelope • VCP-NPL4-UFD1 AAA ATPase complex • perinuclear region of cytoplasm • cnewyllyn cell Prosesau biolegol • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of cell death • positive regulation of protein-containing complex assembly • cytoplasmic sequestering of NF-kappaB • regulation of cell adhesion • GO:1903362 regulation of protein catabolic process • positive regulation of apoptotic process • GO:0097285 apoptotic process • regulation of protein kinase activity • proteasome-mediated ubiquitin-dependent protein catabolic process • marwolaeth celloedd • positive regulation of DNA replication Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11124	n/a
Ensembl	ENSG00000185104	n/a
UniProt	Q9UNN5	n/a
RefSeq (mRNA)	NM_131917 NM_007051	n/a
RefSeq (protein)	NP_008982	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FAF1.

• hFAF1
• CGI-03
• HFAF1s
• UBXD12
• UBXN3A

Llyfryddiaeth

• "Crystallization and preliminary X-ray crystallographic analysis of human FAF1 UBX domain. ". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID 20124726.
• "Fas-associated factor 1 and Parkinson's disease. ". Neurobiol Dis. 2008. PMID 18573343.
• "Sanguinarine exhibits antitumor activity via up-regulation of Fas-associated factor 1 in non-small cell lung cancer. ". J Biochem Mol Toxicol. 2017. PMID 28296008.
• "Validation of Type 2 Diabetes Risk Variants Identified by Genome-Wide Association Studies in Northern Han Chinese. ". Int J Environ Res Public Health. 2016. PMID 27589775.
• "Crystal structure of human FAF1 UBX domain reveals a novel FcisP touch-turn motif in p97/VCP-binding region.". Biochem Biophys Res Commun. 2011. PMID 21414298.