FGB

Protein sy'n cael ei godio yn y corff dynol gan y genyn FGB yw FGB a elwir hefyd yn Fibrinogen beta chain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q31.3.

FGB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FZA, 1FZB, 1FZC, 1FZE, 1FZF, 1FZG, 1LT9, 1LTJ, 1N86, 1N8E, 1RE3, 1RE4, 1RF0, 1RF1, 2A45, 2FFD, 2H43, 2HLO, 2HOD, 2HPC, 2OYH, 2OYI, 2Q9I, 2XNX, 2XNY, 2Z4E, 3BVH, 3E1I, 3GHG, 3H32, 3HUS
Dynodwyr
Cyfenwau	FGB, HEL-S-78p, fibrinogen beta chain
Dynodwyr allanol	OMIM: 134830 HomoloGene: 3772 GeneCards: FGB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein-macromolecule adaptor activity • chaperone binding • structural molecule activity • GO:0001948, GO:0016582 protein binding • signaling receptor binding • cell adhesion molecule binding • extracellular matrix structural constituent Cydrannau o'r gell • cytoplasm • platelet alpha granule • extracellular vesicle • blood microparticle • Cellbilen • fibrinogen complex • extracellular region • cell surface • cell cortex • extracellular exosome • platelet alpha granule lumen • external side of plasma membrane • extracellular space • Reticwlwm endoplasmig • synapse • collagen-containing extracellular matrix Prosesau biolegol • hemostasis • negative regulation of endothelial cell apoptotic process • positive regulation of peptide hormone secretion • protein polymerization • positive regulation of heterotypic cell-cell adhesion • adaptive immune response • fibrinolysis • immune system process • platelet degranulation • blood coagulation • extracellular matrix organization • cellular response to leptin stimulus • response to calcium ion • positive regulation of substrate adhesion-dependent cell spreading • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of vasoconstriction • cellular response to interleukin-1 • positive regulation of protein secretion • positive regulation of ERK1 and ERK2 cascade • positive regulation of exocytosis • blood coagulation, fibrin clot formation • plasminogen activation • innate immune response • cell-matrix adhesion • platelet aggregation • GO:0072468 signal transduction • induction of bacterial agglutination • platelet activation • toll-like receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2244	n/a
Ensembl	ENSG00000171564	n/a
UniProt	P02675	n/a
RefSeq (mRNA)	NM_001184741 NM_005141	n/a
RefSeq (protein)	NP_001171670 NP_005132 NP_001369688 NP_001369689 NP_001369690 NP_001369691 NP_001369692 NP_001369693 NP_001369694	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FGB.

• HEL-S-78p

Llyfryddiaeth

• "Plasma fibrinogen level may be a possible marker for the clinical response and prognosis of patients with breast cancer receiving neoadjuvant chemotherapy. ". Tumour Biol. 2017. PMID 28621233.
• "Prognostic significance of hyperfibrinogenemia in patients with esophageal squamous cell carcinoma. ". Int J Clin Oncol. 2017. PMID 28064398.
• "Succession of splicing regulatory elements determines cryptic 5΄ss functionality. ". Nucleic Acids Res. 2017. PMID 28039323.
• "A novel missense mutation in the FGB gene (p.Gly302Arg) leading to afibrinogenemia. Predicted structure and function consequences. ". Hamostaseologie. 2016. PMID 27824214.
• "A novel mutation in exon 2 of FGB caused by c.221G>T † substitution, predicting the replacement of the native Arginine at position 74 with a Leucine (p.Arg74Leu † ) in a proband from a Kurdish family with dysfibrinogenaemia and familial venous and arterial thrombosis.". J Thromb Thrombolysis. 2017. PMID 27812779.