FGF19

Protein sy'n cael ei godio yn y corff dynol gan y genyn FGF19 yw FGF19 a elwir hefyd yn Fibroblast growth factor 19 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q13.3.

FGF19
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1PWA, 2P23
Dynodwyr
Cyfenwau	FGF19, fibroblast growth factor 19
Dynodwyr allanol	OMIM: 603891 HomoloGene: 3754 GeneCards: FGF19
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • fibroblast growth factor receptor binding • GO:0001948, GO:0016582 protein binding • growth factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity Cydrannau o'r gell • extracellular region • intracellular anatomical structure Prosesau biolegol • positive regulation of glucose import • positive regulation of protein phosphorylation • positive regulation of JNK cascade • negative regulation of gene expression • nervous system development • MAPK cascade • fibroblast growth factor receptor signaling pathway • positive regulation of cell population proliferation • positive regulation of ERK1 and ERK2 cascade • phosphatidylinositol phosphate biosynthetic process • phosphatidylinositol-3-phosphate biosynthetic process • regulation of signaling receptor activity • positive regulation of protein kinase B signaling • neural crest cell migration • heart development • negative regulation of bile acid biosynthetic process • response to bacterium Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9965	n/a
Ensembl	ENSG00000162344	n/a
UniProt	O95750	n/a
RefSeq (mRNA)	NM_005117	n/a
RefSeq (protein)	NP_005108	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Llyfryddiaeth

• "Identification of FGF19 as a prognostic marker and potential driver gene of lung squamous cell carcinomas in Chinese smoking patients. ". Oncotarget. 2016. PMID 26943773.
• "Factors associated with fibroblast growth factor 19 increment after oral glucose loading in patients who were previously admitted for coronary angiography. ". Clin Chim Acta. 2015. PMID 26343925.
• "Circulating FGF19 closely correlates with bile acid synthesis and cholestasis in patients with primary biliary cirrhosis. ". PLoS One. 2017. PMID 28570655.
• "The portal-drained viscera release fibroblast growth factor 19 in humans. ". Physiol Rep. 2016. PMID 28003563.
• "FGF19 Contributes to Tumor Progression in Gastric Cancer by Promoting Migration and Invasion.". Oncol Res. 2016. PMID 27053348.