FGF4

Protein sy'n cael ei godio yn y corff dynol gan y genyn FGF4 yw FGF4 a elwir hefyd yn Fibroblast growth factor 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q13.3.

FGF4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IJT
Dynodwyr
Cyfenwau	FGF4, HBGF-4, HST, HST-1, HSTF1, K-FGF, KFGF, fibroblast growth factor 4, HSTF-1, FGF-4
Dynodwyr allanol	OMIM: 164980 HomoloGene: 1522 GeneCards: FGF4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • heparin binding • fibroblast growth factor receptor binding • growth factor activity • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity Cydrannau o'r gell • extracellular region • intracellular anatomical structure Prosesau biolegol • cartilage condensation • MAPK cascade • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • apoptotic process involved in morphogenesis • GO:0072468 signal transduction • cell-cell signaling • regulation of endothelial cell chemotaxis to fibroblast growth factor • multicellular organism development • embryonic limb morphogenesis • mesenchymal cell proliferation • positive regulation of cell division • regulation of gene expression • GO:1901313 positive regulation of gene expression • stem cell population maintenance • chondroblast differentiation • cranial suture morphogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cell differentiation • positive regulation of protein phosphorylation • odontogenesis of dentin-containing tooth • embryonic hindlimb morphogenesis • fibroblast growth factor receptor signaling pathway • peptidyl-tyrosine phosphorylation • positive regulation of cell population proliferation • phosphatidylinositol phosphate biosynthetic process • phosphatidylinositol-3-phosphate biosynthetic process • cellular response to leukemia inhibitory factor • regulation of signaling receptor activity • positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2249	n/a
Ensembl	ENSG00000075388	n/a
UniProt	P08620	n/a
RefSeq (mRNA)	NM_002007	n/a
RefSeq (protein)	NP_001998	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FGF4.

• HST
• KFGF
• FGF-4
• HST-1
• HSTF1
• K-FGF
• HBGF-4
• HSTF-1

Llyfryddiaeth

• "Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity. ". Lab Invest. 2014. PMID 25329002.
• "Fibroblast growth factor receptor 4 regulates proliferation and antiapoptosis during gastric cancer progression. ". Cancer. 2011. PMID 21567388.
• "Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal. ". Stem Cells. 2008. PMID 18192227.
• "FGF-4 increases in vitro expansion rate of human adult bone marrow-derived mesenchymal stem cells. ". Growth Factors. 2007. PMID 17852409.
• "HST-1/FGF-4 protects male germ cells from apoptosis under heat-stress condition.". Exp Cell Res. 2004. PMID 14980503.