FLNA

Protein sy'n cael ei godio yn y corff dynol gan y genyn FLNA yw FLNA a elwir hefyd yn Filamin-A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xq28.

FLNA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AAV, 2BP3, 2BRQ, 2J3S, 2JF1, 2K3T, 2K7P, 2MTP, 2W0P, 2WFN, 3CNK, 3HOC, 3HOP, 3HOR, 3ISW, 3RGH, 4M9P, 4P3W
Dynodwyr
Cyfenwau	FLNA, ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD, filamin A, FGS2
Dynodwyr allanol	OMIM: 300017 HomoloGene: 1119 GeneCards: FLNA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • GO:0032403 protein-containing complex binding • transcription factor binding • mu-type opioid receptor binding • signal transducer activity • actin filament binding • small GTPase binding • kinase binding • actin binding • SMAD binding • Fc-gamma receptor I complex binding • G protein-coupled receptor binding • GTPase binding • RNA binding • potassium channel regulator activity • transmembrane transporter binding • cadherin binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • bilen • focal adhesion • cortical cytoskeleton • Cellbilen • Myb complex • dendritic shaft • extracellular region • neuronal cell body • cell cortex • nucleolus • Microffilament • actin cytoskeleton • perinuclear region of cytoplasm • extracellular exosome • Cytosgerbwd • cnewyllyn cell • apical dendrite • filamentous actin • GO:0005578 extracellular matrix • cell-cell junction • cytosol • Z disc Prosesau biolegol • actin cytoskeleton reorganization • negative regulation of transcription by RNA polymerase I • GO:1903363 negative regulation of protein catabolic process • establishment of protein localization • protein stabilization • platelet degranulation • mRNA transcription by RNA polymerase II • negative regulation of apoptotic process • receptor clustering • negative regulation of DNA-binding transcription factor activity • cytoplasmic sequestering of protein • platelet activation • mitotic spindle assembly • positive regulation of substrate adhesion-dependent cell spreading • protein localization to cell surface • cell projection organization • adenylate cyclase-inhibiting dopamine receptor signaling pathway • actin crosslink formation • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of integrin-mediated signaling pathway • platelet aggregation • cell junction assembly • regulation of cell migration • wound healing, spreading of cells • semaphorin-plexin signaling pathway • formation of radial glial scaffolds • cerebral cortex development • cilium assembly • protein localization to plasma membrane • positive regulation of potassium ion transmembrane transport • regulation of membrane repolarization during atrial cardiac muscle cell action potential • regulation of membrane repolarization during cardiac muscle cell action potential • positive regulation of neural precursor cell proliferation • positive regulation of neuron migration Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2316	n/a
Ensembl	ENSG00000196924	n/a
UniProt	P21333	n/a
RefSeq (mRNA)	NM_001110556 NM_001456	n/a
RefSeq (protein)	NP_001104026 NP_001447	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FLNA.

• FLN
• FMD
• MNS
• OPD
• ABPX
• CSBS
• CVD1
• FLN1
• NHBP
• OPD1
• OPD2
• XLVD
• XMVD
• FLN-A
• ABP-280

Llyfryddiaeth

• "Lung Transplantation for FLNA-Associated Progressive Lung Disease. ". J Pediatr. 2017. PMID 28457522.
• "Structural and thermodynamic basis of a frontometaphyseal dysplasia mutation in filamin A. ". J Biol Chem. 2017. PMID 28348077.
• "Ehlers-Danlos syndrome with lethal cardiac valvular dystrophy in males carrying a novel splice mutation in FLNA. ". Am J Med Genet A. 2017. PMID 27739212.
• "Cytoskeletal Filamin A Differentially Modulates RNA Polymerase III Gene Transcription in Transformed Cell Lines. ". J Biol Chem. 2016. PMID 27738102.
• "Mammalian target of rapamycin (mTOR) complex 2 regulates filamin A-dependent focal adhesion dynamics and cell migration.". Genes Cells. 2016. PMID 27059097.