FN1

Protein sy'n cael ei godio yn y corff dynol gan y genyn FN1 yw FN1 a elwir hefyd yn Fibronectin , FN1 protein a Fibronectin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q35.

FN1
Strwythurau PDB Human UniProt search: H0Y7Z1%20or%20B7ZLE5 PDBe H0Y7Z1,B7ZLE5 RCSB Rhestr o ddynodwyr PDB 1E88, 1E8B, 1FBR, 1FNA, 1FNF, 1FNH, 1J8K, 1O9A, 1OWW, 1Q38, 1QGB, 1QO6, 1TTF, 1TTG, 2CG6, 2CG7, 2CK2, 2CKU, 2EC3, 2FN2, 2FNB, 2GEE, 2H41, 2H45, 2HA1, 2OCF, 2RKY, 2RKZ, 2RL0, 3CAL, 3EJH, 3GXE, 3M7P, 3MQL, 3R8Q, 3ZRZ, 4GH7, 4JE4, 4JEG, 4LXO, 4MMX, 4MMY, 4MMZ, 4PZ5, 2N1K, 5DC4, 5DC0, 5DC9, 3T1W
Dynodwyr
Cyfenwau	FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, fibronectin 1, SMDCF
Dynodwyr allanol	OMIM: 135600 HomoloGene: 1533 GeneCards: FN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • heparin binding • collagen binding • integrin binding • GO:0001948, GO:0016582 protein binding • identical protein binding • peptidase activator activity • protease binding Cydrannau o'r gell • blood microparticle • GO:0005578 extracellular matrix • fibrinogen complex • extracellular region • basement membrane • apical plasma membrane • extracellular exosome • platelet alpha granule lumen • endoplasmic reticulum-Golgi intermediate compartment • hylif allgellog Prosesau biolegol • regulation of protein phosphorylation • calcium-independent cell-matrix adhesion • endodermal cell differentiation • positive regulation of fibroblast proliferation • positive regulation of substrate-dependent cell migration, cell attachment to substrate • platelet degranulation • extracellular matrix disassembly • wound healing • positive regulation of peptidase activity • GO:0051357, GO:0051358, GO:0051359 peptide cross-linking • cell adhesion • GO:1901313 positive regulation of gene expression • acute-phase response • angiogenesis • positive regulation of cell population proliferation • regulation of cell shape • regulation of ERK1 and ERK2 cascade • cell-substrate junction assembly • substrate adhesion-dependent cell spreading • integrin activation • positive regulation of axon extension • cell-matrix adhesion • leukocyte migration • response to wounding • extracellular matrix organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2335	n/a
Ensembl	ENSG00000115414	n/a
UniProt	P02751	n/a
RefSeq (mRNA)	NM_001306129 NM_001306130 NM_001306131 NM_001306132 NM_002026 NM_054034 NM_212474 NM_212475 NM_212476 NM_212478 NM_212482 NM_001365517 NM_001365518 NM_001365519 NM_001365520 NM_001365521 NM_001365522 NM_001365523 NM_001365524	n/a
RefSeq (protein)	NP_001293058 NP_001293059 NP_001293060 NP_001293061 NP_002017 NP_473375 NP_997639 NP_997641 NP_997643 NP_997647 NP_001352446 NP_001352447 NP_001352448 NP_001352449 NP_001352450 NP_001352451 NP_001352452 NP_001352453 NP_001293058.1 NP_001293059.1 NP_001293061.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FN1.

• FN
• CIG
• FNZ
• MSF
• ED-B
• FINC
• GFND
• LETS
• GFND2
• SMDCF

Llyfryddiaeth

• "Mutations in Fibronectin Cause a Subtype of Spondylometaphyseal Dysplasia with "Corner Fractures". ". Am J Hum Genet. 2017. PMID 29100092.
• "Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. ". J Cell Biol. 2017. PMID 29021221.
• "Fibronectin Conformation and Assembly: Analysis of Fibronectin Deletion Mutants and Fibronectin Glomerulopathy (GFND) Mutants. ". Biochemistry. 2017. PMID 28745050.
• "The expression of fibronectin is significantly suppressed in macrophages to exert a protective effect against Staphylococcus aureus infection. ". BMC Microbiol. 2017. PMID 28407745.
• "ER stress-mediated cell damage contributes to the release of EDA+ fibronectin from hepatocytes in nonalcoholic fatty liver disease.". J Huazhong Univ Sci Technolog Med Sci. 2017. PMID 28397039.