FOXM1

Protein sy'n cael ei godio yn y corff dynol gan y genyn FOXM1 yw FOXM1 a elwir hefyd yn Forkhead box M1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12p13.33.

FOXM1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3G73
Dynodwyr
Cyfenwau	FOXM1, FKHL16, FOXM1B, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TGT3, TRIDENT, forkhead box M1, FOXM1A, FOXM1C
Dynodwyr allanol	OMIM: 602341 HomoloGene: 7318 GeneCards: FOXM1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001948, GO:0016582 protein binding • protein kinase binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cnewyllyn cell • nucleoplasm Prosesau biolegol • positive regulation of double-strand break repair • regulation of Ras protein signal transduction • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:1904489 regulation of reactive oxygen species metabolic process • transcription by RNA polymerase II • transcription, DNA-templated • regulation of cell cycle • cellular response to DNA damage stimulus • regulation of cell population proliferation • G2/M transition of mitotic cell cycle • regulation of cell growth • positive regulation of cell population proliferation • negative regulation of stress-activated MAPK cascade • GO:0045996 negative regulation of transcription, DNA-templated • GO:0100026 DNA repair • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • GO:0009373 regulation of transcription, DNA-templated • anatomical structure morphogenesis • cell differentiation • cell cycle • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2305	n/a
Ensembl	ENSG00000111206	n/a
UniProt	Q08050	n/a
RefSeq (mRNA)	NM_001243088 NM_001243089 NM_021953 NM_202002 NM_202003	n/a
RefSeq (protein)	NP_001230017 NP_001230018 NP_068772 NP_973731 NP_973732	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FOXM1.

• MPP2
• HFH11
• HNF-3
• INS-1
• MPP-2
• PIG29
• FKHL16
• FOXM1B
• HFH-11
• TRIDENT
• MPHOSPH2

Llyfryddiaeth

• "[Forkhead domain inhibitor-6 (FDI-6) increases apoptosis and inhibits invasion and migration of laryngeal carcinoma cells by down-regulating nuclear FoxM1]. ". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017. PMID 28502298.
• "FOXM1 Transcription Factor: A New Component of Chronic Myeloid Leukemia Stem Cell Proliferation Advantage. ". J Cell Biochem. 2017. PMID 28401599.
• "Overexpression of FOXM1 Is a Potential Prognostic Marker in Male Breast Cancer. ". Oncol Res Treat. 2017. PMID 28376490.
• "Tanshinone IIA suppresses gastric cancer cell proliferation and migration by downregulation of FOXM1. ". Oncol Rep. 2017. PMID 28184921.
• "Prognostic significance of FOXM1 expression and antitumor effect of FOXM1 inhibition in synovial sarcomas.". BMC Cancer. 2016. PMID 27439614.