FOXO4

Protein sy'n cael ei godio yn y corff dynol gan y genyn FOXO4 yw FOXO4 a elwir hefyd yn Forkhead box O4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq13.1.

FOXO4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1E17, 3L2C
Dynodwyr
Cyfenwau	FOXO4, AFX, AFX1, MLLT7, forkhead box O4
Dynodwyr allanol	OMIM: 300033 HomoloGene: 4342 GeneCards: FOXO4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • enzyme binding • transcription factor binding • beta-catenin binding • identical protein binding • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • promoter-specific chromatin binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cytosol • cnewyllyn cell • nucleoplasm • nuclear speck Prosesau biolegol • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of smooth muscle cell differentiation • negative regulation of G0 to G1 transition • GO:1901047 insulin receptor signaling pathway • negative regulation of angiogenesis • multicellular organism development • cell differentiation • transcription, DNA-templated • muscle organ development • stem cell differentiation • transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • mitotic G2 DNA damage checkpoint signaling • cell cycle • GO:0009373 regulation of transcription, DNA-templated • negative regulation of cell population proliferation • response to water-immersion restraint stress • response to nutrient levels • GO:0010260 heneiddio • positive regulation of smooth muscle cell migration • protein deubiquitination • GO:1901227 negative regulation of transcription by RNA polymerase II • glucose homeostasis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4303	n/a
Ensembl	ENSG00000184481	n/a
UniProt	P98177	n/a
RefSeq (mRNA)	NM_001170931 NM_005938	n/a
RefSeq (protein)	NP_001164402 NP_005929	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FOXO4.

• AFX
• AFX1
• MLLT7

Llyfryddiaeth

• "The role of microRNA-1274a in the tumorigenesis of gastric cancer: accelerating cancer cell proliferation and migration via directly targeting FOXO4. ". Biochem Biophys Res Commun. 2015. PMID 25753202.
• "Low expression of the FoxO4 gene may contribute to the phenomenon of EMT in non-small cell lung cancer. ". Asian Pac J Cancer Prev. 2014. PMID 24935588.
• "The transcription factor FOXO4 is down-regulated and inhibits tumor proliferation and metastasis in gastric cancer. ". BMC Cancer. 2014. PMID 24886657.
• "FOXO4 is necessary for neural differentiation of human embryonic stem cells. ". Aging Cell. 2013. PMID 23551888.
• "Screening for mutations of the FOXO4 gene in premature ovarian failure patients.". Reprod Biomed Online. 2012. PMID 22285440.