FURIN

Protein sy'n cael ei godio yn y corff dynol gan y genyn FURIN yw FURIN a elwir hefyd yn Furin (Paired basic amino acid cleaving enzyme), isoform CRA_a a Furin, paired basic amino acid cleaving enzyme (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q26.1.

FURIN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4OMC, 4OMD, 4RYD, 4Z2A
Dynodwyr
Cyfenwau	FURIN, FUR, PACE, PCSK3, SPC1, furin, paired basic amino acid cleaving enzyme
Dynodwyr allanol	OMIM: 136950 HomoloGene: 1930 GeneCards: FURIN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nerve growth factor binding • peptide binding • metal ion binding • protease binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • serine-type endopeptidase inhibitor activity • serine-type peptidase activity • hydrolase activity • endopeptidase activity • serine-type endopeptidase activity Cydrannau o'r gell • integral component of membrane • Golgi apparatus • bilen • Cellbilen • cell surface • trans-Golgi network • Reticwlwm endoplasmig • Golgi lumen • membrane raft • trans-Golgi network transport vesicle • extracellular exosome • extracellular space • Golgi membrane • extracellular region • endosome • endosome membrane • integral component of Golgi membrane Prosesau biolegol • negative regulation of low-density lipoprotein particle receptor catabolic process • negative regulation of transforming growth factor beta1 production • GO:0019067 viral life cycle • secretion by cell • peptide biosynthetic process • protein processing • positive regulation of membrane protein ectodomain proteolysis • extracellular matrix disassembly • extracellular matrix organization • viral protein processing • proteolysis • signal peptide processing • peptide hormone processing • regulation of signal transduction • GO:1903362 regulation of protein catabolic process • collagen catabolic process • negative regulation of nerve growth factor production • nerve growth factor processing • nerve growth factor production • cell population proliferation • transforming growth factor beta receptor signaling pathway • regulation of endopeptidase activity • negative regulation of endopeptidase activity • cornification • zymogen activation • regulation of lipoprotein lipase activity • dibasic protein processing • zymogen inhibition • positive regulation of transforming growth factor beta1 activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5045	n/a
Ensembl	ENSG00000140564	n/a
UniProt	P09958	n/a
RefSeq (mRNA)	NM_002569 NM_001289823 NM_001289824	n/a
RefSeq (protein)	NP_001276752 NP_001276753 NP_002560 NP_001369548 NP_001369549 NP_001369550 NP_001369551 NP_001276752.1 NP_001276753.1 NP_002560.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FURIN.

• FUR
• PACE
• SPC1
• PCSK3

Llyfryddiaeth

• "The proprotein convertase furin in tumour progression. ". Int J Cancer. 2017. PMID 28369813.
• "Radiotherapy-associated Furin Expression and Tumor Invasiveness in Recurrent Laryngeal Cancer. ". Anticancer Res. 2016. PMID 27798871.
• "Association of Rs2071410 on Furin with Transient Ischemic Attack Susceptibility and Prognosis in a Chinese Population. ". Med Sci Monit. 2016. PMID 27760099.
• "Cleavage of the HPV16 Minor Capsid Protein L2 during Virion Morphogenesis Ablates the Requirement for Cellular Furin during De Novo Infection. ". Viruses. 2015. PMID 26569287.
• "The Plasma Level of Proprotein Convertase FURIN in Patients with Suspected Infection in the Emergency Room: A Prospective Cohort Study.". Scand J Immunol. 2015. PMID 26346780.