GNA12

Protein sy'n cael ei godio yn y corff dynol gan y genyn GNA12 yw GNA12 a elwir hefyd yn G protein subunit alpha 12 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p22.3-p22.2.

GNA12
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ZCA
Dynodwyr
Cyfenwau	GNA12, NNX3, RMP, gep, G protein subunit alpha 12, HG1M1
Dynodwyr allanol	OMIM: 604394 HomoloGene: 22398 GeneCards: GNA12
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GTP binding • metal ion binding • GO:0001948, GO:0016582 protein binding • guanyl nucleotide binding • G protein-coupled receptor binding • D5 dopamine receptor binding • signal transducer activity • G-protein beta/gamma-subunit complex binding • GO:0006184 GTPase activity Cydrannau o'r gell • bilen • focal adhesion • heterotrimeric G-protein complex • brush border membrane • cytoplasm • Cellbilen • lateral plasma membrane Prosesau biolegol • cell differentiation • GO:0007243 intracellular signal transduction • regulation of TOR signaling • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • small GTPase mediated signal transduction • embryonic digit morphogenesis • blood coagulation • in utero embryonic development • platelet activation • regulation of cell shape • regulation of proteasomal ubiquitin-dependent protein catabolic process • GO:0072468 signal transduction • G protein-coupled receptor signaling pathway • regulation of fibroblast migration • Rho protein signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2768	n/a
Ensembl	ENSG00000146535	n/a
UniProt	Q03113	n/a
RefSeq (mRNA)	NM_001282440 NM_001282441 NM_001293092 NM_007353	n/a
RefSeq (protein)	NP_001269369 NP_001269370 NP_001280021 NP_031379	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GNA12.

• RMP
• gep
• NNX3

Llyfryddiaeth

• "Preeclampsia is Associated with Decreased Methylation of the GNA12 Promoter. ". Ann Hum Genet. 2016. PMID 26767593.
• "Galpha12 Protects Vascular Endothelial Cells from Serum Withdrawal-Induced Apoptosis through Regulation of miR-155. ". Yonsei Med J. 2016. PMID 26632408.
• "Gα12 activation in podocytes leads to cumulative changes in glomerular collagen expression, proteinuria and glomerulosclerosis. ". Lab Invest. 2012. PMID 22249312.
• "Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia. ". Mol Cell Proteomics. 2011. PMID 21986993.
• "G alpha12 is targeted to the mitochondria and affects mitochondrial morphology and motility.". FASEB J. 2008. PMID 18367648.