GNAS

GNAS
Dynodwyr
Cyfenwau	GNAS, AHO, C20orf45, GNAS1, GPSA, GSA, GSP, NESP, POH, SCG6, SgVI, GNAS complex locus, PITA3
Dynodwyr allanol	OMIM: 139320 HomoloGene: 55534 GeneCards: GNAS
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• molecular function; • nucleotide binding; • G-protein beta/gamma-subunit complex binding; • GTP binding; • signal transducer activity; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • GO:0006184 GTPase activity; • guanyl nucleotide binding; • adenylate cyclase activator activity; • insulin-like growth factor receptor binding; • mu-type opioid receptor binding; • corticotropin-releasing hormone receptor 1 binding; • beta-2 adrenergic receptor binding; • ionotropic glutamate receptor binding; • D1 dopamine receptor binding; • G protein-coupled receptor binding;
Cydrannau o'r gell	• cytoplasm; • perinuclear region of cytoplasm; • extracellular region; • transport vesicle; • GO:0016023 cytoplasmic vesicle; • cnewyllyn cell; • cytosol; • trans-Golgi network membrane; • bilen; • Cellbilen; • heterotrimeric G-protein complex; • intrinsic component of membrane; • extracellular exosome; • ruffle; • cell projection; • dendrite; • apical plasma membrane;
Prosesau biolegol	• female pregnancy; • negative regulation of multicellular organism growth; • response to parathyroid hormone; • protein secretion; • positive regulation of cold-induced thermogenesis; • hair follicle placode formation; • cellular response to catecholamine stimulus; • adenylate cyclase-activating dopamine receptor signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • gwybyddiaeth; • regulation of insulin secretion; • cellular response to glucagon stimulus; • intracellular transport; • positive regulation of cAMP-mediated signaling; • activation of adenylate cyclase activity; • cellular response to prostaglandin E stimulus; • adenylate cyclase-activating adrenergic receptor signaling pathway; • sensory perception of smell; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • developmental growth; • renal water homeostasis; • bone development; • platelet aggregation; • GO:0072468 signal transduction; • G protein-coupled receptor signaling pathway; • regulation of signal transduction; • skeletal system development; • genetic imprinting; • multicellular organism growth; • positive regulation of osteoclast differentiation; • endochondral ossification; • regulation of parathyroid hormone secretion; • post-embryonic development; • post-embryonic body morphogenesis; • DNA methylation; • cartilage development; • positive regulation of osteoblast differentiation; • tissue homeostasis; • sensory perception of chemical stimulus; • embryonic cranial skeleton morphogenesis; • energy reserve metabolic process; • skin development; • embryonic hindlimb morphogenesis; • adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • GO:0048554 positive regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologau
	2778
	n/a
	ENSG00000087460
	n/a
	O95467; P63092; P84996; Q5JWF2
	n/a
NM_000516; NM_001077488; NM_001077489; NM_001077490; NM_001309840;
	NM_001309842; NM_001309861; NM_001309883; NM_016592; NM_080425; NM_080426
	n/a
NP_000507; NP_001070956; NP_001070957; NP_001070958; NP_001296769;
	NP_001296771; NP_001296790; NP_001296812; NP_057676; NP_536350; NP_536351; NP_000507.1; NP_001070956.1; NP_001070957.1; NP_001070958.1; NP_001296769.1; NP_536350.2; NP_536351.1; NP_001070958.1; NP_001296812.1; NP_001296812.1; NP_536350.2
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GNAS yw GNAS a elwir hefyd yn Guanine nucleotide-binding protein G(s) subunit alpha isoforms short , Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas a GNAS complex locus (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q13.32.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GNAS.

AHO
GSA
GSP
POH
GPSA
NESP
SCG6
SgVI
GNAS1
PITA3
C20orf45

Llyfryddiaeth

"The GNASR201C mutation associated with clonal hematopoiesis supports transplantable hematopoietic stem cell activity. ". Exp Hematol. 2018. PMID 28939416.
"Mechanical stress affects methylation pattern of GNAS isoforms and osteogenic differentiation of hAT-MSCs. ". Biochim Biophys Acta. 2017. PMID 28483487.
"Progressive Development of PTH Resistance in Patients With Inactivating Mutations on the Maternal Allele of GNAS. ". J Clin Endocrinol Metab. 2017. PMID 28323910.
"Mucinous Cystadenoma in Children and Adolescents. ". J Pediatr Adolesc Gynecol. 2017. PMID 28216128.
"Karyotyping and analysis of GNAS locus in intramuscular myxomas.". Oncotarget. 2017. PMID 28160572.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] GNAS - Cronfa NCBI

[2]

[1]