HLA-DMB

Protein sy'n cael ei godio yn y corff dynol gan y genyn HLA-DMB yw HLA-DMB a elwir hefyd yn HLA class II histocompatibility antigen, DM beta chain a Major histocompatibility complex, class II, DM beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p21.32.

HLA-DMB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HDM, 2BC4, 4FQX, 4GBX, 4I0P
Dynodwyr
Cyfenwau	HLA-DMB, D6S221E, RING7, major histocompatibility complex, class II, DM beta
Dynodwyr allanol	OMIM: 142856 HomoloGene: 68231 GeneCards: HLA-DMB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • MHC class II protein complex binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • lysosomal membrane • lysosome • bilen • endosome • late endosome membrane • integral component of membrane • MHC class II protein complex Prosesau biolegol • positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell • antigen processing and presentation • MHC class II protein complex assembly • positive regulation of T cell proliferation • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • peptide antigen assembly with MHC class II protein complex • immune system process • antigen processing and presentation of exogenous peptide antigen via MHC class II • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • adaptive immune response Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3109	n/a
Ensembl	ENSG00000241674 ENSG00000226264 ENSG00000242574 ENSG00000239329 ENSG00000234154 ENSG00000242386 ENSG00000242092 ENSG00000241296	n/a
UniProt	P28068	n/a
RefSeq (mRNA)	NM_002118	n/a
RefSeq (protein)	NP_002109	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HLA-DMB.

• RING7
• D6S221E

Llyfryddiaeth

• "Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions. ". J Immunol. 2015. PMID 26062997.
• "SNP screening of central MHC-identified HLA-DMB as a candidate susceptibility gene for HIV-related Kaposi's sarcoma. ". Genes Immun. 2014. PMID 25008864.
• "Forced expression of HLA-DM at the surface of dendritic cells increases loading of synthetic peptides on MHC class II molecules and modulates T cell responses. ". J Immunol. 2011. PMID 21622867.
• "Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes. ". J Immunol. 2009. PMID 19767569.
• "Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer.". Clin Cancer Res. 2008. PMID 19047092.