HLA-G

Protein sy'n cael ei godio yn y corff dynol gan y genyn HLA-G yw HLA-G a elwir hefyd yn Major histocompatibility complex, class I, G (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p22.1.

HLA-G
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3KYO, 1YDP, 2D31, 2DYP, 3BZE, 3CDG, 3CII, 3KYN
Dynodwyr
Cyfenwau	HLA-G, MHC-G, major histocompatibility complex, class I, G
Dynodwyr allanol	OMIM: 142871 HomoloGene: 133255 GeneCards: HLA-G
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • signaling receptor binding • peptide antigen binding • GO:0001948, GO:0016582 protein binding • identical protein binding • CD8 receptor binding Cydrannau o'r gell • integral component of membrane • phagocytic vesicle membrane • early endosome membrane • bilen • Golgi membrane • MHC class I protein complex • ER to Golgi transport vesicle membrane • integral component of lumenal side of endoplasmic reticulum membrane • recycling endosome membrane • extracellular region • Cellbilen • endosome • early endosome • Reticwlwm endoplasmig • endoplasmic reticulum membrane • filopodium membrane • cis-Golgi network membrane • cell projection • extracellular space • external side of plasma membrane Prosesau biolegol • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • positive regulation of tolerance induction • positive regulation of interleukin-12 production • interferon-gamma-mediated signaling pathway • immune system process • positive regulation of regulatory T cell differentiation • positive regulation of T cell tolerance induction • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent • cellular defense response • negative regulation of T cell proliferation • negative regulation of immune response • type I interferon signaling pathway • regulation of immune response • immune response-inhibiting cell surface receptor signaling pathway • negative regulation of dendritic cell differentiation • antigen processing and presentation of peptide antigen via MHC class I • negative regulation of T cell mediated cytotoxicity • positive regulation of T cell mediated cytotoxicity • peripheral B cell tolerance induction • antigen processing and presentation of endogenous peptide antigen via MHC class Ib • positive regulation of natural killer cell cytokine production • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • negative regulation of angiogenesis • protection from natural killer cell mediated cytotoxicity • negative regulation of natural killer cell mediated cytotoxicity • negative regulation of protein kinase B signaling • positive regulation of macrophage cytokine production • protein homotrimerization • negative regulation of G0 to G1 transition • positive regulation of endothelial cell apoptotic process • positive regulation of cellular senescence • antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3135	n/a
Ensembl	ENSG00000230413 ENSG00000233095 ENSG00000237216 ENSG00000276051 ENSG00000204632 ENSG00000235346 ENSG00000235680 ENSG00000206506	n/a
UniProt	P17693	n/a
RefSeq (mRNA)	NM_002127 NM_001363567 NM_001384280 NM_001384290	n/a
RefSeq (protein)	NP_002118 NP_001350496	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HLA-G.

• MHC-G

Llyfryddiaeth

• "HLA-G variability and haplotypes detected by massively parallel sequencing procedures in the geographicaly distinct population samples of Brazil and Cyprus. ". Mol Immunol. 2017. PMID 28135606.
• "Mesenchymal stem cells upregulate Treg cells via sHLA-G in SLE patients. ". Int Immunopharmacol. 2017. PMID 28129605.
• "HLA-G molecules and clinical outcome in Chronic Myeloid Leukemia. ". Leuk Res. 2017. PMID 28841441.
• "HLA-G: At the Interface of Maternal-Fetal Tolerance. ". Trends Immunol. 2017. PMID 28279591.
• "HLA-G 3'UTR gene polymorphisms and rheumatic heart disease: a familial study among South Indian population.". Pediatr Rheumatol Online J. 2017. PMID 28143491.