HOMER1

HOMER1
Dynodwyr
Cyfenwau	HOMER1, HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1, homer scaffolding protein 1, homer scaffold protein 1
Dynodwyr allanol	OMIM: 604798 HomoloGene: 3155 GeneCards: HOMER1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transmembrane transporter binding; • signaling adaptor activity; • GO:0001948, GO:0016582 protein binding; • G protein-coupled glutamate receptor binding;
Cydrannau o'r gell	• cytoplasm; • postsynaptic membrane; • bilen; • GO:0097483, GO:0097481 postsynaptic density; • Cellbilen; • apical part of cell; • synapse; • axon; • cell junction; • Z discdkac; • neuron projection; • costamere; • postsynapse; • cytosol; • neuron spine; • cell projection; • dendritic spine; • dendrite; • glutamatergic synapse; • postsynaptic cytosol;
Prosesau biolegol	• phospholipase C-activating G protein-coupled glutamate receptor signaling pathway; • positive regulation of signal transduction; • behavioral response to cocaine; • skeletal muscle contraction; • regulation of calcium ion import; • response to calcium ion; • chemical homeostasis within a tissue; • skeletal muscle fiber development; • positive regulation of calcium ion transport; • chemical synaptic transmission; • regulation of cation channel activity; • regulation of store-operated calcium entry; • protein tetramerization; • regulation of synaptic transmission, glutamatergic; • regulation of dendritic spine maintenance; • G protein-coupled glutamate receptor signaling pathway; • regulation of postsynaptic neurotransmitter receptor activity;
	Sources:Amigo / QuickGO
Orthologau
	9456
	n/a
	ENSG00000152413
	n/a
	Q86YM7
	n/a
	NM_004272; NM_001277077; NM_001277078
	n/a
	NP_001264006; NP_001264007; NP_004263
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HOMER1 yw HOMER1 a elwir hefyd yn Homer scaffolding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q14.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HOMER1.

HOMER
SYN47
Ves-1
HOMER1A
HOMER1B
HOMER1C

Llyfryddiaeth

"Association of common genetic variants of HOMER1 gene with levodopa adverse effects in Parkinson's disease patients. ". Pharmacogenomics J. 2014. PMID 24126708.
"The uncoupling of synaptic protein homer 1c from target proteins activates store-operated calcium entry in a neurotransmitter-like manner in human neuroblastoma cells. ". Dokl Biol Sci. 2013. PMID 23821062.
"Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells. ". Oncol Rep. 2016. PMID 26718835.
"Signaling pathways regulating Homer1a expression: implications for antidepressant therapy. ". Biol Chem. 2016. PMID 26641965.
"Identification of Homer1 as a potential prognostic marker for intrahepatic cholangiocarcinoma.". Asian Pac J Cancer Prev. 2014. PMID 24815486.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HOMER1 - Cronfa NCBI

[2]

[1]