HSPD1

Protein sy'n cael ei godio yn y corff dynol gan y genyn HSPD1 yw HSPD1 a elwir hefyd yn Heat shock protein family D (Hsp60) member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q33.1.

HSPD1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4PJ1
Dynodwyr
Cyfenwau	HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13, heat shock protein family D (Hsp60) member 1
Dynodwyr allanol	OMIM: 118190 HomoloGene: 1626 GeneCards: HSPD1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • chaperone binding • p53 binding • single-stranded DNA binding • ATPase activity • GO:0001948, GO:0016582 protein binding • double-stranded RNA binding • DNA replication origin binding • ATP binding • ubiquitin protein ligase binding • protein folding chaperone activity • unfolded protein binding • RNA binding • hydrolase activity • high-density lipoprotein particle binding • enzyme binding • apolipoprotein binding • apolipoprotein A-I binding • lipopolysaccharide binding • isomerase activity Cydrannau o'r gell • cytoplasm • cyclin-dependent protein kinase activating kinase holoenzyme complex • lipopolysaccharide receptor complex • early endosome • mitocondria • clathrin-coated pit • coated vesicle • extracellular exosome • GO:0005578 extracellular matrix • mitochondrial matrix • extracellular space • mitochondrial inner membrane • cytosol • Cellbilen • cell surface • bilen • secretory granule • GO:0009327 protein-containing complex Prosesau biolegol • chaperone-mediated protein complex assembly • positive regulation of interleukin-12 production • positive regulation of interleukin-10 production • protein stabilization • protein maturation • positive regulation of macrophage activation • MyD88-dependent toll-like receptor signaling pathway • isotype switching to IgG isotypes • B cell activation • B cell cytokine production • response to unfolded protein • B cell proliferation • protein folding • positive regulation of T cell mediated immune response to tumor cell • protein refolding • positive regulation of interleukin-6 production • positive regulation of apoptotic process • response to cold • GO:0022415 viral process • activation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • 'de novo' protein folding • protein import into mitochondrial intermembrane space • chaperone-mediated protein folding • apoptotic mitochondrial changes • positive regulation of interferon-alpha production • positive regulation of interferon-gamma production • T cell activation • negative regulation of apoptotic process • positive regulation of T cell activation • mitochondrion organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3329	n/a
Ensembl	ENSG00000144381	n/a
UniProt	P10809	n/a
RefSeq (mRNA)	NM_002156 NM_199440	n/a
RefSeq (protein)	NP_002147 NP_955472	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HSPD1.

• HLD4
• CPN60
• GROEL
• HSP60
• HSP65
• SPG13
• HSP-60
• HuCHA60

Llyfryddiaeth

• "27-Hydroxycholesterol upregulates the production of heat shock protein 60 of monocytic cells. ". J Steroid Biochem Mol Biol. 2017. PMID 28549691.
• "Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis. ". Sci Rep. 2015. PMID 26672742.
• "Tolerization against atherosclerosis using heat shock protein 60. ". Cell Stress Chaperones. 2016. PMID 26577462.
• "HSP60: a double edge sword in autoimmunity. ". Oncotarget. 2015. PMID 26431161.
• "Anti-citrullinated protein antibodies promote apoptosis of mature human Saos-2 osteoblasts via cell-surface binding to citrullinated heat shock protein 60.". Immunobiology. 2016. PMID 26275591.