IGFBP4

Protein sy'n cael ei godio yn y corff dynol gan y genyn IGFBP4 yw IGFBP4 a elwir hefyd yn Insulin like growth factor binding protein 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.2.

IGFBP4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WQJ, 2DSP, 2DSQ, 2DSR
Dynodwyr
Cyfenwau	IGFBP4, BP-4, HT29-IGFBP, IBP4, IGFBP-4, insulin like growth factor binding protein 4
Dynodwyr allanol	OMIM: 146733 HomoloGene: 1192 GeneCards: IGFBP4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • insulin-like growth factor I binding • insulin-like growth factor II binding • signaling receptor binding • insulin-like growth factor binding • growth factor binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • extracellular region • extracellular space • endoplasmic reticulum lumen Prosesau biolegol • skeletal system development • regulation of growth • DNA metabolic process • regulation of insulin-like growth factor receptor signaling pathway • regulation of glucose metabolic process • cell population proliferation • inflammatory response • positive regulation of insulin-like growth factor receptor signaling pathway • type B pancreatic cell proliferation • negative regulation of canonical Wnt signaling pathway • regulation of cell growth • GO:0072468 signal transduction • positive regulation of MAPK cascade • post-translational protein modification Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3487	n/a
Ensembl	ENSG00000141753	n/a
UniProt	P22692	n/a
RefSeq (mRNA)	NM_001552	n/a
RefSeq (protein)	NP_001543	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IGFBP4.

• BP-4
• IBP4
• IGFBP-4
• HT29-IGFBP

Llyfryddiaeth

• "Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells. ". J Immunol. 2017. PMID 28724578.
• "Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis. ". PLoS One. 2016. PMID 27019456.
• "IGFBP-4 Fragments as Markers of Cardiovascular Mortality in Type 1 Diabetes Patients With and Without Nephropathy. ". J Clin Endocrinol Metab. 2015. PMID 26046968.
• "PAPP-A and IGFBP-4 fragment levels in patients with ST-elevation myocardial infarction treated with heparin and PCI. ". Clin Biochem. 2015. PMID 25489725.
• "IBP regulates epithelial-to-mesenchymal transition and the motility of breast cancer cells via Rac1, RhoA and Cdc42 signaling pathways.". Oncogene. 2014. PMID 23975422.