IL10

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL10 yw IL10 a elwir hefyd yn Interleukin 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q32.1.

IL10
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ILK, 1INR, 1J7V, 1LK3, 1Y6K, 2ILK, 2H24
Dynodwyr
Cyfenwau	IL10, CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin 10
Dynodwyr allanol	OMIM: 124092 HomoloGene: 478 GeneCards: IL10
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • growth factor activity • cytokine activity • interleukin-10 receptor binding • protein dimerization activity Cydrannau o'r gell • extracellular region • extracellular space Prosesau biolegol • negative regulation of chronic inflammatory response to antigenic stimulus • positive regulation of MHC class II biosynthetic process • negative regulation of endothelial cell apoptotic process • hemopoiesis • negative regulation of interferon-gamma production • regulation of sensory perception of pain • positive regulation of B cell apoptotic process • negative regulation of chemokine (C-C motif) ligand 5 production • response to inactivity • negative regulation of cytokine activity • negative regulation of interleukin-1 production • cellular response to hepatocyte growth factor stimulus • cellular response to estradiol stimulus • negative regulation of interleukin-6 production • GO:0010260 heneiddio • positive regulation of DNA-binding transcription factor activity • negative regulation of apoptotic process • GO:0002719 negative regulation of cytokine production involved in immune response • response to glucocorticoid • cytoplasmic sequestering of NF-kappaB • negative regulation of interleukin-18 production • negative regulation of MHC class II biosynthetic process • response to activity • response to organic substance • response to carbon monoxide • leukocyte chemotaxis • type 2 immune response • negative regulation of myeloid dendritic cell activation • response to insulin • negative regulation of interleukin-8 production • response to lipopolysaccharide • B cell proliferation • negative regulation of T cell proliferation • negative regulation of nitric oxide biosynthetic process • branching involved in labyrinthine layer morphogenesis • defense response to bacterium • regulation of complement-dependent cytotoxicity • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • regulation of gene expression • B cell differentiation • regulation of isotype switching • negative regulation of tumor necrosis factor production • negative regulation of membrane protein ectodomain proteolysis • inflammatory response • cellular response to lipopolysaccharide • negative regulation of B cell proliferation • negative regulation of inflammatory response • GO:0032697 negative regulation of cytokine production • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of interleukin-12 production • defense response to protozoan • negative regulation of sensory perception of pain • positive regulation of macrophage activation • liver regeneration • GO:1904739 regulation of synapse organization • positive regulation of endothelial cell proliferation • negative regulation of cell population proliferation • negative regulation of heterotypic cell-cell adhesion • positive regulation of heterotypic cell-cell adhesion • positive regulation of cell cycle • negative regulation of mitotic cell cycle • endothelial cell apoptotic process • regulation of response to wounding • negative regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • interleukin-12-mediated signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of autophagy • cytokine-mediated signaling pathway • positive regulation of receptor signaling pathway via JAK-STAT • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of hydrogen peroxide-induced neuron death • positive regulation of sprouting angiogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3586	n/a
Ensembl	ENSG00000136634	n/a
UniProt	P22301	n/a
RefSeq (mRNA)	NM_000572	n/a
RefSeq (protein)	NP_000563	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL10.

• CSIF
• TGIF
• GVHDS
• IL-10
• IL10A

Llyfryddiaeth

• "Association of interleukin-10 gene single nucleotide polymorphisms with susceptibility to systemic lupus erythematosus in a Chinese population. ". Gene. 2018. PMID 29199038.
• "Association of Systemic Inflammatory and Anti-inflammatory Responses with Adverse Outcomes in Acute Pancreatitis: Preliminary Results of an Ongoing Study. ". Dig Dis Sci. 2017. PMID 29080144.
• "Interleukin-10-regulated tumour tolerance in non-small cell lung cancer. ". Br J Cancer. 2017. PMID 29016555.
• "IL10 Release upon PD-1 Blockade Sustains Immunosuppression in Ovarian Cancer. ". Cancer Res. 2017. PMID 28993412.
• "Alzheimer's disease and cytokine IL-10 gene polymorphisms: is there an association?". Arq Neuropsiquiatr. 2017. PMID 28977146.