IL12B

IL12B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1F42, 1F45, 3D85, 3D87, 3DUH, 3HMX, 3QWR, 4GRW, 4OE8, 4OG9
Dynodwyr
Cyfenwau	IL12B, CLMF, CLMF2, IL-12B, IMD28, NKSF, NKSF2, IMD29, Interleukin 12 subunit beta, interleukin 12B
Dynodwyr allanol	OMIM: 161561 HomoloGene: 1648 GeneCards: IL12B
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• cytokine activity; • interleukin-23 receptor binding; • protein homodimerization activity; • interleukin-12 receptor binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • protein heterodimerization activity; • interleukin-12 alpha subunit binding; • GO:0016518 cytokine receptor activity; • growth factor activity; • GO:0005145 cytokine receptor binding; • GO:0019974 cytokine binding;
Cydrannau o'r gell	• cytoplasm; • bilen; • interleukin-12 complex; • interleukin-23 complex; • extracellular region; • extracellular space; • endoplasmic reticulum lumen; • cytosol; • late endosome lumen; • cell surface; • external side of plasma membrane; • receptor complex;
Prosesau biolegol	• positive regulation of cell adhesion; • negative regulation of interleukin-10 production; • negative regulation of smooth muscle cell proliferation; • positive regulation of inflammatory response; • sexual reproduction; • positive regulation of interleukin-12 production; • positive regulation of smooth muscle cell apoptotic process; • GO:0051636 defense response to Gram-negative bacterium; • positive regulation of interleukin-10 production; • positive regulation of T cell mediated cytotoxicity; • natural killer cell activation; • positive regulation of natural killer cell activation; • positive regulation of interferon-gamma production; • positive regulation of osteoclast differentiation; • positive regulation of T-helper 17 cell lineage commitment; • response to organic substance; • positive regulation of NK T cell activation; • positive regulation of natural killer cell proliferation; • natural killer cell activation involved in immune response; • cell surface receptor signaling pathway; • positive regulation of NK T cell proliferation; • positive regulation of T-helper 17 type immune response; • negative regulation of inflammatory response to antigenic stimulus; • defense response to virus; • positive regulation of tissue remodeling; • positive regulation of T-helper 1 type immune response; • positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; • positive regulation of granulocyte macrophage colony-stimulating factor production; • positive regulation of T cell proliferation; • positive regulation of memory T cell differentiation; • cellular response to interferon-gamma; • positive regulation of tumor necrosis factor production; • T-helper 1 type immune response; • sensory perception of pain; • response to UV-B; • positive regulation of interleukin-17 production; • cellular response to lipopolysaccharide; • negative regulation of interleukin-17 production; • T-helper cell differentiation; • cell migration; • positive regulation of lymphocyte proliferation; • positive regulation of mononuclear cell proliferation; • positive regulation of activated T cell proliferation; • defense response to protozoan; • positive regulation of defense response to virus by host; • positive regulation of activation of Janus kinase activity; • regulation of tyrosine phosphorylation of STAT protein; • positive regulation of tyrosine phosphorylation of STAT protein; • interleukin-12-mediated signaling pathway; • cell population proliferation; • regulation of signaling receptor activity; • T-helper 1 cell cytokine production; • cytokine-mediated signaling pathway; • interleukin-23-mediated signaling pathway; • positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologau
	3593
	n/a
	ENSG00000113302
	n/a
	P29460
	n/a
	NM_002187
	n/a
	NP_002178
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL12B yw IL12B a elwir hefyd yn Interleukin 12B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q33.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL12B.

CLMF
NKSF
CLMF2
IMD28
IMD29
NKSF2
IL-12B

Llyfryddiaeth

"Interleukin-12B gene polymorphisms and bronchial asthma risk: A meta-analysis. ". J Asthma. 2017. PMID 28287286.
"An interleukin 12 B single nucleotide polymorphism increases IL-12p40 production and is associated with increased disease susceptibility in patients with relapsing-remitting multiple sclerosis. ". Neurol Res. 2017. PMID 28276258.
"Single nucleotide polymorphisms of IL12B are associated with Takayasu arteritis in Chinese Han population. ". Rheumatol Int. 2017. PMID 28160070.
"High Interleukin-12 Levels May Prevent an Increase in the Amount of Fungi in the Gastrointestinal Tract during the First Years of Diabetes Mellitus Type 1. ". Dis Markers. 2016. PMID 28127111.
"IL-12B Gene Polymorphisms and IL-12 p70 Serum Levels Among Patients with Rheumatoid Arthritis.". Scand J Immunol. 2017. PMID 27896842.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] IL12B - Cronfa NCBI

[2]

[1]