IL6R

IL6R
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1N26, 1P9M, 2ARW
Dynodwyr
Cyfenwau	IL6R, CD126, IL-6R-1, IL-6RA, IL6Q, IL6RA, IL6RQ, gp80, Interleukin-6 receptor, interleukin 6 receptor
Dynodwyr allanol	OMIM: 147880 HomoloGene: 474 GeneCards: IL6R
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• ciliary neurotrophic factor receptor activity; • protein homodimerization activity; • interleukin-6 receptor binding; • GO:0001948, GO:0016582 protein binding; • GO:0016518 cytokine receptor activity; • enzyme binding; • ciliary neurotrophic factor binding; • interleukin-6 receptor activity; • interleukin-6 binding; • interleukin-12 receptor binding; • growth factor activity; • GO:0019974 cytokine binding; • interleukin-12 alpha subunit binding; • interleukin-23 receptor binding;
Cydrannau o'r gell	• integral component of membrane; • bilen; • Cellbilen; • extracellular region; • basolateral plasma membrane; • apical plasma membrane; • interleukin-6 receptor complex; • ciliary neurotrophic factor receptor complex; • extracellular space; • cell surface; • external side of plasma membrane; • receptor complex; • interleukin-12 complex; • interleukin-23 complex;
Prosesau biolegol	• positive regulation of activation of Janus kinase activity; • response to cytokine; • hepatic immune response; • extrinsic apoptotic signaling pathway; • monocyte chemotaxis; • ciliary neurotrophic factor-mediated signaling pathway; • positive regulation of leukocyte chemotaxis; • negative regulation of interleukin-8 production; • positive regulation of osteoblast differentiation; • GO:0051636 defense response to Gram-negative bacterium; • acute-phase response; • positive regulation of NF-kappaB transcription factor activity; • positive regulation of cell population proliferation; • positive regulation of interleukin-6 production; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of chemokine production; • neutrophil mediated immunity; • negative regulation of collagen biosynthetic process; • endocrine pancreas development; • positive regulation of MAPK cascade; • positive regulation of smooth muscle cell proliferation; • GO:0051637 defense response to Gram-positive bacterium; • positive regulation of tyrosine phosphorylation of STAT protein; • cytokine-mediated signaling pathway; • interleukin-6-mediated signaling pathway; • positive regulation of T-helper 1 type immune response; • regulation of signaling receptor activity; • positive regulation of interferon-gamma production; • positive regulation of natural killer cell activation; • positive regulation of activated T cell proliferation; • positive regulation of lymphocyte proliferation; • positive regulation of NK T cell activation; • positive regulation of glomerular mesangial cell proliferation;
	Sources:Amigo / QuickGO
Orthologau
	3570
	n/a
	ENSG00000160712
	n/a
	P08887
	n/a
	NM_000565; NM_001206866; NM_181359
	n/a
NP_000556; NP_001193795; NP_852004; NP_001369698; NP_001369699;
	NP_001369700; NP_001369701; NP_001369702; NP_001369703
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL6R yw IL6R a elwir hefyd yn Interleukin 6 receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q21.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL6R.

IL6Q
gp80
CD126
IL6RA
IL6RQ
IL-6RA
IL-6R-1

Llyfryddiaeth

"Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma. ". Hum Mol Genet. 2017. PMID 28334838.
"Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation. ". PLoS Biol. 2017. PMID 28060820.
"Clinical significance of GCF sIL-6R and calprotectin to evaluate the periodontal inflammation. ". Ann Clin Biochem. 2017. PMID 27810997.
"Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation. ". J Immunol. 2016. PMID 27698010.
"Interleukin-6 receptor in spindle-shaped stromal cells, a prognostic determinant of early breast cancer.". Tumour Biol. 2016. PMID 27460086.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] IL6R - Cronfa NCBI

[2]

[1]