KCNH2

Protein sy'n cael ei godio yn y corff dynol gan y genyn KCNH2 yw KCNH2 a elwir hefyd yn Potassium voltage-gated channel subfamily H member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q36.1.

KCNH2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BYW, 1UJL, 2L0W, 2L1M, 2L4R, 2LE7, 4HP9, 4HQA, 2N7G
Dynodwyr
Cyfenwau	KCNH2, ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1, LQT2, SQT1, potassium voltage-gated channel subfamily H member 2
Dynodwyr allanol	OMIM: 152427 HomoloGene: 201 GeneCards: KCNH2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • potassium channel activity • protein homodimerization activity • scaffold protein binding • voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization • C3HC4-type RING finger domain binding • voltage-gated ion channel activity • ion channel activity • GO:0001948, GO:0016582 protein binding • identical protein binding • voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization • voltage-gated potassium channel activity • phosphorelay sensor kinase activity • ubiquitin protein ligase binding • delayed rectifier potassium channel activity • inward rectifier potassium channel activity Cydrannau o'r gell • integral component of membrane • bilen • voltage-gated potassium channel complex • Cellbilen • cell surface • perinuclear region of cytoplasm • inward rectifier potassium channel complex • integral component of plasma membrane Prosesau biolegol • membrane depolarization during action potential • cardiac muscle contraction • GO:0072468 signal transduction • regulation of membrane potential • regulation of ion transmembrane transport • ventricular cardiac muscle cell action potential • cludo ïon • potassium ion export across plasma membrane • potassium ion transport • membrane repolarization during action potential • potassium ion homeostasis • regulation of heart rate by hormone • transmembrane transport • potassium ion transmembrane transport • positive regulation of potassium ion transmembrane transport • phosphorelay signal transduction system • regulation of membrane repolarization • negative regulation of potassium ion transmembrane transport • membrane repolarization during cardiac muscle cell action potential • regulation of heart rate by cardiac conduction • regulation of potassium ion transmembrane transport • regulation of ventricular cardiac muscle cell membrane repolarization • membrane repolarization during ventricular cardiac muscle cell action potential • membrane repolarization • negative regulation of potassium ion export across plasma membrane • potassium ion import across plasma membrane • cardiac conduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3757	n/a
Ensembl	ENSG00000055118	n/a
UniProt	Q12809	n/a
RefSeq (mRNA)	NM_000238 NM_001204798 NM_172056 NM_172057	n/a
RefSeq (protein)	NP_000229 NP_001191727 NP_742053 NP_742054	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KCNH2.

• ERG1
• HERG
• LQT2
• SQT1
• ERG-1
• H-ERG
• HERG1
• Kv11.1

Llyfryddiaeth

• "The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues. ". Biophys J. 2017. PMID 29117522.
• "Upregulation of functional Kv11.1a isoform expression by modified U1 small nuclear RNA. ". Gene. 2018. PMID 29066300.
• "Hypoxia reduces mature hERG channels through calpain up-regulation. ". FASEB J. 2017. PMID 28784631.
• "Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG. ". Cell. 2017. PMID 28431243.
• "Comparative study of the structure and interaction of the pore helices of the hERG and Kv1.5 potassium channels in model membranes.". Eur Biophys J. 2017. PMID 28314880.