KLK3

Protein sy'n cael ei godio yn y corff dynol gan y genyn KLK3 yw KLK3 a elwir hefyd yn Prostate-specific antigen a Kallikrein related peptidase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.33.

KLK3
Strwythurau PDB Human UniProt search: M0QZF9 PDBe M0QZF9 RCSB Rhestr o ddynodwyr PDB 2ZCH, 2ZCK, 2ZCL, 3QUM
Dynodwyr
Cyfenwau	KLK3, APS, KLK2A1, PSA, hK3, kallikrein related peptidase 3, Prostate Specific Antigen
Dynodwyr allanol	OMIM: 176820 HomoloGene: 68141 GeneCards: KLK3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0070122 peptidase activity • serine-type peptidase activity • endopeptidase activity • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides • GO:0001948, GO:0016582 protein binding • hydrolase activity • serine-type endopeptidase activity Cydrannau o'r gell • extracellular exosome • cnewyllyn cell • extracellular region • extracellular space • secretory granule • GO:0009327 protein-containing complex Prosesau biolegol • negative regulation of angiogenesis • antibacterial peptide production • proteolysis • regulation of systemic arterial blood pressure • zymogen activation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	354	n/a
Ensembl	ENSG00000142515	n/a
UniProt	P07288	n/a
RefSeq (mRNA)	NM_001030047 NM_001030048 NM_001030049 NM_001030050 NM_001648 NM_145864	n/a
RefSeq (protein)	NP_001025218 NP_001025219 NP_001639	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KLK3.

• APS
• PSA
• hK3
• KLK2A1

Llyfryddiaeth

• "Increased PSA expression on prostate cancer exosomes in in vitro condition and in cancer patients. ". Cancer Lett. 2017. PMID 28694142.
• "PSA declines and survival in patients with metastatic castration-resistant prostate cancer treated with enzalutamide: A retrospective case-report study. ". Medicine (Baltimore). 2017. PMID 28614217.
• "Chronic Periodontitis Does Not Impact Serum Levels of Prostate-specific Antigen. ". Anticancer Res. 2017. PMID 28551659.
• "Single-nucleotide polymorphism rs1058205 of KLK3 is associated with the risk of prostate cancer: A case-control study of Han Chinese men in Northeast China. ". Medicine (Baltimore). 2017. PMID 28272245.
• "Detection of Prostate Cancer Metastasis by Whole Body Magnetic Resonance Imaging Combined with Bone Scintigraphy and PSA Levels.". Cell Physiol Biochem. 2016. PMID 27941343.