LIG1

Protein sy'n cael ei godio yn y corff dynol gan y genyn LIG1 yw LIG1 a elwir hefyd yn DNA ligase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.33.

LIG1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X9N
Dynodwyr
Cyfenwau	LIG1, DNA ligase 1, LIGI, hLig1, IMD96
Dynodwyr allanol	OMIM: 126391 HomoloGene: 197 GeneCards: LIG1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • nucleotide binding • DNA ligase (ATP) activity • metal ion binding • ligase activity • ATP binding • DNA ligase activity Cydrannau o'r gell • intracellular membrane-bounded organelle • nucleoplasm • mitocondria • cnewyllyn cell • cytoplasm Prosesau biolegol • nucleotide-excision repair, DNA gap filling • DNA recombination • DNA biosynthetic process • anatomical structure morphogenesis • Okazaki fragment processing involved in mitotic DNA replication • cellular response to DNA damage stimulus • Cellraniad • DNA replication • V(D)J recombination • DNA mismatch repair • DNA ligation involved in DNA repair • cell cycle • transcription-coupled nucleotide-excision repair • GO:0100026 DNA repair • base-excision repair • DNA ligation • lagging strand elongation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3978	n/a
Ensembl	ENSG00000105486	n/a
UniProt	P18858	n/a
RefSeq (mRNA)	NM_000234 NM_001289063 NM_001289064 NM_001320970 NM_001320971	n/a
RefSeq (protein)	NP_000225 NP_001275992 NP_001275993 NP_001307899 NP_001307900	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Llyfryddiaeth

• "Association Between the LIG1 Polymorphisms and Lung Cancer Risk: A Meta-analysis of Case-Control Studies. ". Cell Biochem Biophys. 2015. PMID 27352326.
• "Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells. ". PLoS One. 2015. PMID 26151554.
• "Relationship between genetic polymorphisms of DNA ligase 1 and non-small cell lung cancer susceptibility and radiosensitivity. ". Genet Mol Res. 2015. PMID 26125914.
• "LIG1 polymorphisms: the Indian scenario. ". J Genet. 2014. PMID 25189241.
• "Human DNA ligase i (ligi) gene and risk of cervical cancer in North Indian women.". Exp Oncol. 2013. PMID 24084463.