LMO2

Protein sy'n cael ei godio yn y corff dynol gan y genyn LMO2 yw LMO2 a elwir hefyd yn LIM domain only 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p13.

LMO2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2XJY, 2XJZ, 2YPA, 4KFZ
Dynodwyr
Cyfenwau	LMO2, RBTN2, RBTNL1, RHOM2, TTG2, LIM domain only 2, LMO-2
Dynodwyr allanol	OMIM: 180385 HomoloGene: 4072 GeneCards: LMO2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • bHLH transcription factor binding • E-box binding • GO:0001948, GO:0016582 protein binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • metal ion binding Cydrannau o'r gell • cnewyllyn cell • transcription regulator complex • nucleoplasm Prosesau biolegol • multicellular organism development • mRNA transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular response to thyroid hormone stimulus • regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4005	n/a
Ensembl	ENSG00000135363	n/a
UniProt	P25791	n/a
RefSeq (mRNA)	NM_001142315 NM_001142316 NM_005574	n/a
RefSeq (protein)	NP_001135787 NP_001135788 NP_005565	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LMO2.

• TTG2
• LMO-2
• RBTN2
• RHOM2
• RBTNL1

Llyfryddiaeth

• "LMO2-negative Expression Predicts the Presence of MYC Translocations in Aggressive B-Cell Lymphomas. ". Am J Surg Pathol. 2017. PMID 28288039.
• "Activation of the LMO2oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia. ". Blood. 2017. PMID 28270453.
• "Overexpression of LMO2 causes aberrant human T-Cell development in vivo by three potentially distinct cellular mechanisms. ". Exp Hematol. 2016. PMID 27302866.
• "LMO2 Is a Specific Marker of T-Lymphoblastic Leukemia/Lymphoma. ". Am J Clin Pathol. 2016. PMID 26796495.
• "The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells.". Cell Death Differ. 2015. PMID 25721045.